We show that a physical trigger, a non-ionizing infrared (IR) radiation at wavelengths strongly absorbed by liquid water, can be used to induce and kinetically control protein (periodic) self-assembly in solution. This phenomenon is explained by considering the effect of IR light on the structuring of protein interfacial water. Our results indicate that the IR radiation can promote enhanced mutual correlations of water molecules in the protein hydration shell. We report on the radiation-induced increase in both the strength and cooperativeness of H-bonds. The presence of a structured dipolar hydration layer can lead to attractive interactions between like-charged biomacromolecules in solution (and crystal nucleation events). Furthermore, our study suggests that enveloping the protein within a layer of structured solvent (an effect enhanced by IR light) can prevent the protein non-specific aggregation favoring periodic self-assembly. Recognizing the ability to affect protein-water interactions by means of IR radiation may have important implications for biological and bio-inspired systems.

This paper investigates whether the model uncertainty of reinforced recycled aggregate concrete (RAC) beams subjected to bending differs from that of reinforced natural aggregate concrete (NAC) beams. An introductory remark concerning the importance of the codification of RAC structural design is made and notions concerning model uncertainties and their role on structural codification are given. Afterwards, the criteria used in the construction of a database of RAC and NAC beams are referred before presenting the key findings of an analysis on the model uncertainty of the cracking, yielding and ultimate moments of beams subjected to four-point bending tests. The analytical moments were calculated following Eurocode 2 provisions. Probabilistic models for model uncertainties are proposed. Negligible differences in the model uncertainty of NAC and RAC beams are reported.

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Hybrid materials have been widely studied for structural applications. Polysaccharide-based fibers, especially cellulosic fibers, have been explored in the last two decades as substitutes of the traditional reinforcements made of glass or carbon fibers due to their mechanical properties. However, their biocompatibility, biodegradability, and chemistry have attracted the researchers and new developments in the field of smart and functional materials arise in diverse applications. This chapter will focus on the biomedical applications of polysaccharide-based smart and functional materials, namely those concerning biosensors and actuators, theranostic systems, and tissue-engineering applications. Special attention will be given to cellulose- and chitin/chitosan-based hybrid materials because these are the two most abundant polysaccharides and probably the most promising for the development of hybrid materials for biomedical applications. Biomimetic strategies for the development of smart and functional hybrid materials will also be highlighted. © 2017 Elsevier Ltd All rights reserved.

TThis chapter concerns the need to evaluate the reliability of structural elements produced with recycled aggregates concrete (RAC) in order to address some designers’ scepticism towards the use of this eco-friendly material. The current knowledge on RAC’s behaviour demonstrates its viability for structural purposes. However, of the investigations performed so far very few are related to a fundamental aspect towards RAC world-wide application as a structural material: structural codes have a probabilistic basis.After briefly presenting the state-of-the-art knowledge on the material properties and structural behaviour of RAC, the limitations of the current knowledge are debated. Afterwards, an introduction to structural codification is presented, as well as the fundamentals of reliability analysis. Examples of code verifications are contextualized with their underlying assumptions and the information necessary for code calibration is discussed. The role of reliability in the calibration of structural codes is shown, common techniques for reliability calculations are briefly explained, and relevant references in the area are cited for the readers’ perusal.Having established how structural codes are calibrated, the state-of-the-art on the probabilistic and statistical knowledge of RAC properties is reviewed. The implications of the very reduced number of studies on this area are discussed and the need to conduct further studies is emphasized.Afterwards, investigations that used reliability analysis to calibrate partial safety factors applicable to RAC are reviewed. The methodology of each investigation is presented, the experimental tests that led to the definition of the probabilistic information of the RAC’s parameters are described and the need to have a wide range of data coming from different RAC compositions and aggregate sources is debated.This chapter finishes by contextualizing the current knowledge on RAC properties with the necessary information for code calibration procedures. The relevance of a code proposal towards RAC affirmation as a structural material is highlighted, as well as the requirements of such code. Suggestions for future studies are made.

© 2017 American Chemical Society. Recent findings have reported the reason why some living beings are able to withstand the huge thermal amplitudes between winter and summer in their natural habitats. They are able to produce metabolites decreasing deeply the crystallization temperature of water, avoiding cell disrupture due to the presence of ice crystals and overcoming osmotic effects. In vitro, the possibility to cool living cells and tissues to cryogenic temperatures in the absence of ice can be achieved through a vitrification process. Vitrification has been suggested as an alternative approach to cryopreservation and could hereafter follow an interesting biomimetic perspective. The metabolites produced by these animals are mostly sugars, organic acids, choline derivatives, or urea. When combined at a particular composition, these compounds form a new liquid phase which has been defined as Natural Deep Eutectic Solvents (NADES). In this review, we relate the findings of different areas of knowledge from evolutive biology, cryobiology, and thermodynamics and give a perspective to the potential of NADES in the development of new cryoprotective agents.

Oxide electronic materials provide a plethora of possible applications and offer ample opportunity for scientists to probe into some of the exciting and intriguing phenomena exhibited by oxide systems and oxide interfaces. In addition to the already diverse spectrum of properties, the nanoscale form of oxides provides a new dimension of hitherto unknown phenomena due to the increased surface-to-volume ratio. Oxide electronic materials are becoming increasingly important in a wide range of applications including transparent electronics, optoelectronics, magnetoelectronics, photonics, spintronics, thermoelectrics, piezoelectrics, power harvesting, hydrogen storage and environmental waste management. Synthesis and fabrication of these materials, as well as processing into particular device structures to suit a specific application is still a challenge. Further, characterization of these materials to understand the tunability of their properties and the novel properties that evolve due to their nanostructured nature is another facet of the challenge. The research related to the oxide electronic field is at an impressionable stage, and this has motivated us to contribute with a roadmap on 'oxide electronic materials and oxide interfaces'. This roadmap envisages the potential applications of oxide materials in cutting edge technologies and focuses on the necessary advances required to implement these materials, including both conventional and novel techniques for the synthesis, characterization, processing and fabrication of nanostructured oxides and oxide-based devices. The contents of this roadmap will highlight the functional and correlated properties of oxides in bulk, nano, thin film, multilayer and heterostructure forms, as well as the theoretical considerations behind both present and future applications in many technologically important areas as pointed out by Venkatesan. The contributions in this roadmap span several thematic groups which are represented by the following authors: novel field effect transistors and bipolar devices by Fortunato, Grundmann, Boschker, Rao, and Rogers; energy conversion and saving by Zaban, Weidenkaff, and Murakami; new opportunities of photonics by Fompeyrine, and Zuniga-Perez; multiferroic materials including novel phenomena by Ramesh, Spaldin, Mertig, Lorenz, Srinivasan, and Prellier; and concepts for topological oxide electronics by Kawasaki, Pentcheva, and Gegenwart. Finally, Miletto Granozio presents the European action 'towards oxide-based electronics' which develops an oxide electronics roadmap with emphasis on future nonvolatile memories and the required technologies. In summary, we do hope that this oxide roadmap appears as an interesting up-to-date snapshot on one of the most exciting and active areas of solid state physics, materials science, and chemistry, which even after many years of very successful development shows in short intervals novel insights and achievements.

The Ørsted Dal Member of the Upper Triassic Fleming Fjord Formation in East Greenland is well known for its rich vertebrate fauna, represented by numerous specimens of both body and ichnofossils. In particular, the footprints of theropod dinosaurs have been described. Recently, an international expedition discovered several slabs with 100 small chirotheriid pes and manus imprints (pes length 4–4.5 cm) in siliciclastic deposits of this unit. They show strong similarities with Brachychirotherium, a characteristic Upper Triassic ichnogenus with a global distribution. A peculiar feature in the Fleming Fjord specimens is the lack of a fifth digit, even in more deeply impressed imprints. Therefore, the specimens are assigned here tentatively to cf. Brachychirotherium. Possibly, this characteristic is related to the extremely small size and early ontogenetic stage of the trackmaker. The record from Greenland is the first evidence of this morphotype from the Fleming Fjord Formation. Candidate trackmakers are crocodylian stem group archosaurs; however, a distinct correlation with known osteological taxa from this unit is not currently possible. While the occurrence of sauropodomorph plateosaurs in the bone record links the Greenland assemblage more closer to that from the Germanic Basin of central Europe, here the described footprints suggest a Pangaea-wide exchange.Supplementary material: Three-dimensional model of cf. Brachychirotherium pes–manus set (from MGUH 31233b) from the Upper Triassic Fleming Fjord Formation (Norian–Rhaetian) of East Greenland as pdf, ply and jpg files (3D model created by Oliver Wings; photographs taken by Jesper Milàn) is available at https://doi.org/10.6084/m9.figshare.c.2133546

Many errors in spreadsheet formulas can be avoided if spreadsheets are built automatically from higher-level models that can encode and enforce consistency constraints in the generated spreadsheets. Employing this strategy for legacy spreadsheets is difficult, because the model has to be reverse engineered from an existing spreadsheet and existing data must be transferred into the new model-generated spreadsheet. We have developed and implemented a technique that automatically infers relational schemas from spreadsheets. This technique uses particularities from the spreadsheet realm to create better schemas. We have evaluated this technique in two ways: First, we have demonstrated its applicability by using it on a set of real-world spreadsheets. Second, we have run an empirical study with users. The study has shown that the results produced by our technique are comparable to the ones developed by experts starting from the same (legacy) spreadsheet data. Although relational schemas are very useful to model data, they do not fit well spreadsheets as they do not allow to express layout. Thus, we have also introduced a mapping between relational schemas and ClassSheets. A ClassSheet controls further changes to the spreadsheet and safeguards it against a large class of formula errors. The developed tool is a contribution to spreadsheet (reverse) engineering, because it fills an important gap and allows a promising design method (ClassSheets) to be applied to a huge collection of legacy spreadsheets with minimal effort.