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The effective stress transfer between the fiber reinforced polymers (FRP) and the steel substrate is crucial for the successful retrofit of existing steel structures with FRP composites. However, there are no standard tests for FRP-to-steel interfaces, wherefore different test configurations have been used in recent years to assess the bond behaviour in these interfaces. The present study shows that the choice of test configuration is highly important and leads to different transfer stresses between the FRP and steel composites and consequently, has a direct influence on the strength of the bonded joint. Therefore, it is important to understand the debonding process that occurs in each test and avoid misinterpretations, erroneous analyses and dangerous characterizations of the interfacial behaviour of these interfaces. The current study presents a new analytical approach for the prediction of the debonding of FRP-to-steel interfaces when double-lap pull or double-strap tests are used.

This article presents a nonlinear analytical solution for the prediction of the full-range debonding response of mechanically anchored, fiber-reinforced polymer (FRP) composites from the substrate. The nonlinear analytical approach predicts, for any monotonic loading history or bonded length, the relative displacements (or slips) between materials, the strains in the FRP composite, the bond stresses within the interface, and the stresses developed in the substrate. The load-slip responses of FRP-to-substrate interfaces with short and long bonded lengths are motives of analysis and discussion. The solutions obtained from the proposed approach are also compared with other experimental results found in the literature.

Additive manufacturing (commonly known as 3D printing or rapid prototyping) refers to processes used to produce parts in an additive manner by means of computer-aided design (CAD). While additive manufacturing is a technology that can be used in many different application areas, this project focuses on future trends in additive manufacturing (AM) aimed at improving biological functionality (bio-AM) and on its opportunities, barriers and challenges. The big advantage of this technique is that small batches can be produced more economically than with any other manufacturing process. Virtually any structure can be customized, which is particularly important in the healthcare sector. Possible applications include biological implants such as organs and tissues, nutrients, drugs and their transport mechanisms, equipment such as surgical knives and drilling guides, tissues for research, development and training, and personalized prostheses, supports and exoskeletons. Besides exploring such applications, the project will also systematically analyze potential "human enhancement" uses of AM technology and developments in the emerging do-it-yourself (DIY) cultures ("bio/body-hacking"; cyborgism; open source 3D printing movement).

In the first phase of the project, the technological state of the art will be analyzed, as will a wide variety of non-technical aspects, regulatory issues and future trends, also with a special focus on sociotechnical imaginaries (e.g., in science fiction), human enhancement and DIY cultures. This horizon scanning will be accomplished partly by means of expert and stakeholder interviews.

In the second phase, the project will use a variety of foresight and technology assessment methods and will carry out a 360° envisioning exercise with contributions by external experts, entailing an in-depth analysis of selected applications of bio-AM.

The project work will end with a scenario development phase in which the focus will be on likely outcomes of already emerging developments, though further-reaching future perspectives will be taken into account to a certain extent. Taken together, these scenarios will allow for both a broader understanding of the wide range of potential impacts of AM applications and a clearer picture of potential policy challenges relevant to the Members of the European Parliament.

ABSTRACTThe fossil record of post-Paleozoic lungfishes in Greenland is currently restricted to a few brief reports of isolated and undetermined tooth plates coming from the uppermost Fleming Fjord Formation (late Norian) in Jameson Land, central East Greenland. Here, we describe Ceratodus tunuensis, sp. nov., a new dipnoan from a thin bed of calcareous lake mudstone from the ?rsted Dal Member of the Fleming Fjord Formation. The Ceratodus fossil record indicates that during the Late Triassic, this genus was restricted to the middle latitudes of the Northern Hemisphere. This record matches previous paleobiogeographical analyses and indicates that terrestrial biota during the Late Triassic was strongly influenced by paleolatitude.Citation for this article: Agnolin, F. L., O. Mateus, J. Milàn, M. Marzola, O. Wings, J. Schulz Adolfssen, and L. B. Clemmensen. 2018. Ceratodus tunuensis, sp. nov., a new lungfish (Sarcopterygii, Dipnoi) from the Upper Triassic of central East Greenland. Journal of Vertebrate Paleontology. DOI: 10.1080/02724634.2018.1439834.

ABSTRACT Diplodocid sauropods had a unique skull morphology, with posteriorly retracted nares, an elongated snout, and anteriorly restricted, peglike teeth. Because of the lack of extant analogs in skull structure and tooth morphology, understanding their feeding strategy and diet has been difficult. Furthermore, the general rarity of sauropod skulls and the fragility of their facial elements resulted in a restricted knowledge of cranial anatomy, in particular regarding the internal surface of the facial skull. Here, we describe in detail a well-preserved diplodocid skull visible in medial view. Diagnostic features recognized in other skulls observable in lateral view, such as the extended contribution of the jugal to the antorbital fenestra, are obliterated in medial view due to extensive overlapping joints between the maxilla, jugal, quadratojugal, and the lacrimal. These overlapping joints permitted limited anterior sliding movement of the snout, which likely served as a kind of ?shock-absorbing? mechanism during feeding. Diplodocid skulls therefore seem to have evolved to alleviate stresses inflicted on the snout during backward movements of the head, as would be expected during branch-stripping or raking.ABSTRACT Diplodocid sauropods had a unique skull morphology, with posteriorly retracted nares, an elongated snout, and anteriorly restricted, peglike teeth. Because of the lack of extant analogs in skull structure and tooth morphology, understanding their feeding strategy and diet has been difficult. Furthermore, the general rarity of sauropod skulls and the fragility of their facial elements resulted in a restricted knowledge of cranial anatomy, in particular regarding the internal surface of the facial skull. Here, we describe in detail a well-preserved diplodocid skull visible in medial view. Diagnostic features recognized in other skulls observable in lateral view, such as the extended contribution of the jugal to the antorbital fenestra, are obliterated in medial view due to extensive overlapping joints between the maxilla, jugal, quadratojugal, and the lacrimal. These overlapping joints permitted limited anterior sliding movement of the snout, which likely served as a kind of ?shock-absorbing? mechanism during feeding. Diplodocid skulls therefore seem to have evolved to alleviate stresses inflicted on the snout during backward movements of the head, as would be expected during branch-stripping or raking.

The adhesively bonded joints behaviour under cyclic loading is not yet well understood due to its inherent complexity. Numerical approaches appear, therefore, as the easiest way to simulate such mechanical behaviour. In this work, double strap bonded joints with Carbon Fibres Reinforced Polymers (CFRP) and aluminium are numerically simulated and subjected to a cyclic loading history. In the numerical simulation, the Distinct Element Method (DEM) is used and it is assumed cohesive bi-linear bond-slip models with local damage of the interface. The evaluation of the bonded joints under cyclic loading is made by comparing the results with those simulated with a monotonic loading.

Cellulosomes are highly sophisticated molecular nanomachines that participate in the deconstruction of complex polysaccharides, notably cellulose and hemicellulose. Cellulosomal assembly is orchestrated by the interaction of enzyme-borne dockerin (Doc) modules to tandem cohesin (Coh) modules of a non-catalytic primary scaffoldin. In some cases, as exemplified by the cellulosome of the major cellulolytic ruminal bacterium Ruminococcus flavefaciens, primary scaffoldins bind to adaptor scaffoldins that further interact with the cell surface via anchoring scaffoldins, thereby increasing cellulosome complexity. Here we elucidate the structure of the unique Doc of R. flavefaciens FD-1 primary scaffoldin ScaA, bound to Coh 5 of the adaptor scaffoldin ScaB. The RfCohScaB5-DocScaA complex has an elliptical architecture similar to previously described complexes from a variety of ecological niches. ScaA Doc presents a single-binding mode, analogous to that described for the other two Coh-Doc specificities required for cellulosome assembly in R. flavefaciens. The exclusive reliance on a single-mode of Coh recognition contrasts with the majority of cellulosomes from other bacterial species described to date, where Docs contain two similar Coh-binding interfaces promoting a dual-binding mode. The discrete Coh-Doc interactions observed in ruminal cellulosomes suggest an adaptation to the exquisite properties of the rumen environment.

Overexpression of the Thomsen-Friedenreich (TF) antigen in cell membrane proteins occurs in 90% of adenocarcinomas. Additionally, the binding of the TF-antigen to human galectin-3 (Gal-3), also frequently overexpressed in malignancy, promotes cancer progression and metastasis. In this context, structures that interfere with this specific interaction display the potential to prevent cancer metastasis. Herein, a multidisciplinary approach, combining the optimized synthesis of a TF-antigen mimetic with NMR, X-ray crystallography methods and isothermal titration calorimetry assays has been employed to unravel the molecular structural details that govern the Gal-3/TF-mimetic interaction. The TF-mimetic presents a binding affinity for Gal-3 similar to the TF-natural antigen and retains the binding epitope and the bioactive conformation observed for the native antigen. Furthermore, from a thermodynamic perspective a decrease in the enthalpic contribution was observed for the Gal-3/TF-mimetic complex, however this behaviour is compensated by a favourable entropy gain. From a structural perspective, these results establish our TF-mimetic as a scaffold to design multivalent solutions to potentially interfere with Gal-3 aberrant interactions and likely be used to hamper Gal-3-mediated cancer cells adhesion and metastasis.