The Bench 19 Bonebed at Bentiaba, Angola, is a unique concentration of marine vertebrates preserving six species of mosasaurs in sediments best correlated by magnetostratigraphy to chron C32n.1n between 71.4 and 71.64 Ma. The bonebed formed at a paleolatitude near 24°S, with an Atlantic width at that latitude approximating 2700 km, roughly half that of the current width. The locality lies on an uncharacteristically narrow continental shelf near transform faults that controlled the coastal outline of Africa in the formation of the South Atlantic Ocean. Biostratigraphic change through the Bentiaba section indicates that the accumulation occurred in an ecological time dimension within the 240 ky bin delimited by chron 32n.1n. The fauna occurs in a 10 m sand unit in the Mocuio Formation with bones and partial skeletons concentrated in, but not limited to, the basal 1–2 m. The sediment entombing the fossils is an immature feldspathic sand shown by detrital zircon ages to be derived from nearby granitic shield rocks. Specimens do not appear to have a strong preferred orientation and they are not concentrated in a strand line. Stable oxygen isotope analysis of associated bivalve shells indicates a water temperature of 18.5°C. The bonebed is clearly mixed with scattered dinosaur and pterosaur elements in a marine assemblage. Gut contents, scavenging marks and associated shed shark teeth in the Bench 19 Fauna indicate biological association and attrition due to feeding activities. The ecological diversity of mosasaur species is shown by tooth and body-size disparity and by δ13C analysis of tooth enamel, which indicate a variety of foraging areas and dietary niches. The Bench 19 Fauna was formed in arid latitudes along a coastal desert similar to that of modern Namibia on a narrow, tectonically controlled continental shelf, in shallow waters below wave base. The area was used as a foraging ground for diverse species, including molluscivorus Globidens phosphaticus, small species expected near the coast, abundant Prognathodon kianda, which fed on other mosasaurs at Bench 19, and species that may have been transient and opportunistic feeders in the area.

As people have become increasingly aware, the age of the European population is rising and the percentage of adults aged 65 years and older is expected to increase. In addition, older people spend about 20 hours per day indoors, and many of them spend essentially their time in elderly care centers (ECC). In this sense, the study of indoor environments and how elder people may be particularly at risk of adverse health effects from pollutants, even at low exposures, due to multiple underlying chronic diseases is becoming an important issue to be addressed by research. Such conditions are highly prevalent, multifactorial, and associated with multiple comorbidities and poor outcomes, such as increased disability and decreased quality of life. The importance of this topic was heightened in 2012 by the World Health Day in 2012 Ageing and health with the theme "Good health adds life to years" and also the ?European Year for Active Ageing and Solidarity between Generations?. Accordingly, this project is suitable to integrate these initiatives and to ensure greater recognition of what older people bring to society and create more supportive conditions for them. To our knowledge, this is the first study in Portugal to assess effects of indoor air contaminants on health status and quality of life in older persons living in ECC. The aim of GERIA project is to carry out a risk assessment, often difficult for older people, involving the identification of multiple factors potentially affecting health and quality of life, the quantification of human exposure to pollutants, and the evaluation of the individual?s response to these stimuli. The results of this project contribute to the understanding of health effects due to indoor environment variables and to provide health benefits to ECC residents with relatively simple measures.

http://docentes.fct.unl.pt/lblm/files/jbic-2015-20-821.pdf

Let $G$ be a graph whose edges are coloured with $k$ colours, and $\mathcal H=(H_1,\dots , H_k)$ be a $k$-tuple of graphs. A \emph{monochromatic $\mathcal H$-decomposition} of $G$ is a partition of the edge set of $G$ such that each part is either a single edge or forms a monochromatic copy of $H_i$ in colour $i$, for some $1\le i\le k$. Let $\phi_{k}(n,\mathcal H)$ be the smallest number $\phi$, such that, for every
order-$n$ graph and every $k$-edge-colouring, there is a monochromatic $\mathcal H$-decomposition with at most $\phi$ elements. Extending the previous results of Liu and Sousa [``Monochromatic $K_r$-decompositions of graphs", \emph{Journal of Graph Theory}76:89-100,2014], we solve this problem
when each graph in $\mathcal H$ is a clique and $n\ge n_0(\mathcal H)$ is sufficiently large.

Neste artigo é apresentado um jogo sério que visa auxiliar a iniciação da aprendizagem do Princípio Alfabético
(discriminação auditiva dos sons das vogais) em crianças com dificuldades na aprendizagem (em particular
com alterações na consciência fonológica). Para isso são estudados vários motores de jogo e o conceito de elearning. São mostrados os vários cenários do jogo bem como as suas funcionalidades e propósitos. Este jogo
foi criado para capacitar instituições de apoio a crianças com perturbações do neurodesenvolvimento.

Abstract Biodegradable polymers such as poly(lactic) acid (PLA) have been studied for biomaterials applications such as natural human ligament replacement, however these materials could be applied to other sectors as aerospace, aeronautics, automotive, food packaging. \{PLA\} presents a relatively brittle with a mode I fracture behavior, being often blend with other biodegradable or non-degradable polymers to improve its fracture energy. For some existing applications, \{PLA\} components exhibit accumulated permanent deformation resulting from dynamic mechanical inputs, resulting on failure by laxity of parts. Aiming the improvement of \{PLA\} mechanical properties, the inclusion of carbon nanofillers into \{PLA\} matrix, in particular, CNT-COOH and \{GNP\} have been developed, due to their strong sp2 carbon-carbon bondings and their geometric arrangement that enhance mechanical properties of the polymer matrix. \{PLA\} and nanocomposites were produced by melt blending followed by compression molding in a hot press, with small weight percentages of nanofillers added to the matrix. Quasi static tensile tests were performed on a mechanical testing machine (Instron™ ElectroPuls E1000) along with failure analysis of specimens with centered crack with digital image correlation, revealing strain distribution along specimens.

X-ray intensity ratios, such as the Kα2/Kα1 ratio, are parameters with a large application in atomic physics and related scientific and technological areas. D.

Glucans are polymers of D-glucose with differing linkages in linear or branched sequences. They are constituents of microbial and plant cell-walls and involved in important bio-recognition processes including immunomodulation, anti-cancer activities, pathogen virulence and plant cell-wall biodegradation. Translational possibilities for these activities in medicine and biotechnology are considerable. High-throughput micro-methods are needed to screen proteins for recognition of specific glucan sequences as a lead to structure-function studies and their exploitation. We describe construction of a glucome microarray, the first sequence-defined glycome-scale microarray, using a designer approach from targeted ligand-bearing glucans in conjunction with a novel high-sensitivity mass spectrometric sequencing method, as a screening tool to assign glucan recognition motifs. The glucome microarray comprises 153 oligosaccharide probes with high purity, representing major sequences in glucans. The negative-ion electrospray tandem mass spectrometry with collision-induced dissociation was used for complete linkage analysis of gluco-oligosaccharides in linear homo and hetero and branched sequences. The system is validated using antibodies and carbohydrate-binding modules known to target α- or β-glucans in different biological contexts, extending knowledge on their specificities, and applied to reveal new information on glucan recognition by two signalling molecules of the immune system against pathogens: Dectin-1 and DC-SIGN. The sequencing of the glucan oligosaccharides by the MS method and their interrogation on the microarrays provides detailed information on linkage, sequence and chain length requirements of glucan-recognizing proteins, and are a sensitive means of revealing unsuspected sequences in the polysaccharides.

Transparent metal oxides thin films are a class of inorganic conductors and semiconductors with significant importance for use in portable electronics, displays, flexible electronics, multi-functional windows and solar cells. Due to the recent development of transparent and flexible electronics, there is a growing interest in depositing metal-oxide thin-film on plastic substrates that can offer flexibility, lighter weight, and potentially lead to cheaper manufacturing by allowing printing and roll- to-roll processing. The plastic substrates, however, limit device processing to below 200oC. In this context, the deposition of high-performance semiconductor thin films from dispersions of pre-prepared oxide nanoparticles at temperatures below 200oC represents a potential key route. This paper reports on the preparation of ZnO transparent thin films using solution- processed nanoparticles (NPs) precipitated from zinc acetate alcoholic solution with potassium hydroxide. The nanoparticles size distribution, microstructure and crystallinity were measured by dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The thin films were deposited by spin-coating onto soda lima glass substrate, using a dispersion of 1wt{%} ZnO NPs. The morphology of the films annealed at 120 and 180oC, observed by atomic force microscopy and cross-section scanning electron microscopy, shows columnar grains with diameter ranging between 20 and 70 nm, depending on the conditions of depositions. Optical measurements indicated high transparency, between 85 and 94 {%}, in the visible range, a direct nature of band-to-band transitions and band gap values between 3,22 and 3,32 eV. The refractive index and extinction coefficient have been calculated from optical transmittance and reflectance spectra.

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cAMP signaling in the brain mediates several higher order neural processes. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels directly bind cAMP through their cytoplasmic cyclic nucleotide binding domain (CNBD), thus playing a unique role in brain function. Neuronal HCN channels are also regulated by tetratricopeptide repeat-containing Rab8b interacting protein (TRIP8b), an auxiliary subunit that antagonizes the effects of cAMP by interacting with the channel CNBD. To unravel the molecular mechanisms underlying the dual regulation of HCN channel activity by cAMP/TRIP8b, we determined the NMR solution structure of the HCN2 channel CNBD in the cAMP-free form and mapped on it the TRIP8b interaction site. We reconstruct here the full conformational changes induced by cAMP binding to the HCN channel CNBD. Our results show that TRIP8b does not compete with cAMP for the same binding region; rather, it exerts its inhibitory action through an allosteric mechanism, preventing the cAMP-induced conformational changes in the HCN channel CNBD.

Radiation Physics and Chemistry, 98 + (2014) 132-149. doi:10.1016/j.radphyschem.2014.01.015