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2014
Rybarczyk, Y., Coelho, T., Cardoso, T., and De Oliveira R. "Effect of avatars and viewpoints on performance in virtual world: efficiency vs. telepresence." EAI Endorsed Transactions on Creative Technologies. 14.1 (2014): e4.Website
Mallison, H., D. Schwarz-Wings, H. Tsai, C. Holliday, and O. Mateus. "Fossil longbone cartilage preserved in stegosaurs?" Journal of Vertebrate Paleontology. Program and Abstracts, 2014 (2014): 176.mallison_et_al._2014_fossil_longbone_cartilage_preserved_in_stegosaurs.pdf
Ribeiro, D., M. Freitas, SM Tomé, AM Silva, G. Porto, E. J. Cabrita, M. M. Marques, and E. Fernandes. "Inhibition of LOX by flavonoids: a structure-activity relationship study." European Journal of Medicinal Chemistry. 72 (2014): 137-145. AbstractWebsite

The lipoxygenase (LOX) products have been identified as mediators of a series of inflammatory diseases, namely rheumatoid arthritis, inflammatory bowel disease, psoriasis, allergic rhinitis, atherosclerosis and certain types of cancer. Hence, LOX inhibitors are of interest for the modulation of these phenomena and resolution of the inflammatory processes. During LOX activity, peroxyl radical complexes are part of the reaction and may function as sources of free radicals. Thus antioxidants, such as flavonoids, capable of inhibiting lipid peroxidation and scavenging free radicals, may act as LOX inhibitors. The aim of this work was to assess the structure–activity relationship among a series of flavonoids concerning 5-LOX inhibition, through a systematic study of the inhibition of the formation of LTB4 in human neutrophils. The type of inhibition of the flavonoids was further studied using soybean LOX, type I, and Saturation Transfer Difference 1H NMR (STD-1H NMR) was used to characterize the binding epitopes of the compounds to LOX-1. The obtained results reinforce flavonoids as effective inhibitors of LTB4 production in human neutrophils. It was also possible to establish a structure/activity relationship for the inhibitory activity and the type of inhibition.

Young, M. T., S. Hua, L. Steel, D. Foffa, S. L. Brusatte, S. Thüring, O. Mateus, J. Ignacio-Ruiz Omeñaca, Y. Lepage, P. Havilk, and M. B. Andrade. "Revision of the Late Jurassic teleosaurid genus Machimosaurus (Crocodylomorpha, Thalattosuchia)." Royal Society Open Science. 1.140222 (2014): 1-42.young_et_al_2014_machimosaurus_crocodylomorph_revision.pdf
Holwerda, F., E. Tschopp, and O. Mateus Sauropod body fossils in Europe: overview and current issues. XII EAVP Meeting XII Annual Meeting of the European Association of Vertebrate Palaeontologists – Abstract Book. Torino 24-28 June 2014, 2014.holwerda_et_al_2014_sauropods_europe_eavp.pdf
Tschopp, E., O. Mateus, R. Kosma, M. Sander, U. Joger, and O. Wings. "A specimen-level cladistic analysis of Camarasaurus (Dinosauria, Sauropoda) and a revision of camarasaurid taxonomy." Journal of Vertebrate Paleontology. Program and Abstracts, 2014 (2014): 241-242.tschopp_et_al._2014_a_specimen-level_cladistic_analysis_of_camarasaurus.pdf
Strganac, C., J. Salminen, LL Jacobs, M. J. Polcyn, KM Ferguson, O. Mateus, AS Schulp, ML Morais, TS Tavares, and A. O. Gon?alves. "Carbon isotope stratigraphy, magnetostratigraphy, and 40Ar/39Ar age of the cretaceous South Atlantic coast, Namibe Basin, Angola." Journal of African Earth Sciences. 99 (2014): 452-462. Abstract
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Teixeira, RT, AM Fortes, C. Pinheiro, and H. Pereira. "Comparison of good- and bad-quality cork: application of high-throughput sequencing of phellogenic tissue." Journal of Experimental Botany (2014). Abstract
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Teixeira, RT, AM Fortes, C. Pinheiro, and H. Pereira. "Comparison of good- and bad-quality cork: application of high-throughput sequencing of phellogenic tissue." Journal of Experimental Botany (2014). Abstract
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Heleno, R., C. Garcia, P. Jordano, A. Traveset, J. M. Gómez, N. Blüthgen, J. Memmott, M. Moora, J. Cerdeira, S. Rodríguez-Echeverría, H. Freitas, and J. M. Olesen. "Ecological networks: Delving into the architecture of biodiversity." Biology Letters. 10 (2014). Abstract
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Araujo-Martins, J., Carreiro P. Martins, J. Viegas, D. Aelenei, MM Cano, JP Teixeira, P. Paixão, AL Papoila, P. Leiria-Pinto, C. Pedro, and others. "Environment and Health in Children Day Care Centres (ENVIRH)–Study rationale and protocol." Revista portuguesa de pneumologia. 20 (2014): 311-323. Abstract

Background Indoor air quality (IAQ) is considered an important determinant of human health. The association between exposure to volatile organic compounds, particulate matter, house dust mite, molds and bacteria in day care centers (DCC) is not completely clear. The aim of this project was to study these effects. Methods ? study design This study comprised two phases. Phase I included an evaluation of 45 DCCs (25 from Lisbon and 20 from Oporto, targeting 5161 children). In this phase, building characteristics, indoor CO2 and air temperature/relative humidity, were assessed. A children's respiratory health questionnaire derived from the ISAAC (International Study on Asthma and Allergies in Children) was also distributed. Phase II encompassed two evaluations and included 20 DCCs selected from phase I after a cluster analysis (11 from Lisbon and 9 from Oporto, targeting 2287 children). In this phase, data on ventilation, IAQ, thermal comfort parameters, respiratory and allergic health, airway inflammation biomarkers, respiratory virus infection patterns and parental and child stress were collected. Results In Phase I, building characteristics, occupant behavior and ventilation surrogates were collected from all DCCs. The response rate of the questionnaire was 61.7% (3186 children). Phase II included 1221 children. Association results between DCC characteristics, IAQ and health outcomes will be provided in order to support recommendations on IAQ and children's health. A building ventilation model will also be developed. Discussion This paper outlines methods that might be implemented by other investigators conducting studies on the association between respiratory health and indoor air quality at DCC.

Godinho, Maria Helena, Ralf Stannarius, and Carsten Tschierske European Conference on Liquid Crystals. Taylor & Francis, 2014. Abstract
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Patrício, P., Paulo Ivo Cortez Teixeira, AC Trindade, and M. H. Godinho. "Longitudinal versus polar wrinkling of core-shell fibers with anisotropic size mismatches." Physical Review E. 89.1 (2014): 012403. Abstract
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Sa, Sofia, Manoj B. Gawande, Alexandre Velhinho, Joao Pedro Veiga, Nenad Bundaleski, Joao Trigueiro, Alexander Tolstogouzov, Orlando M. N. D. Teodoro, Radek Zboril, Rajender S. Varma, and Paula S. Branco. "Magnetically recyclable magnetite-palladium (Nanocat-Fe-Pd) nanocatalyst for the Buchwald-Hartwig reaction." Green Chemistry. 16 (2014): 3494-3500. AbstractWebsite
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Tendeiro, Diogo, Gonçalo Lopes, Pedro Vieira, and Jose Paulo Santos. "Monte Carlo simulation of laser beams interaction with the human eye using Geant4." BioMedical Engineering OnLine. 13 (2014): 58. AbstractWebsite
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Tendeiro, Diogo, Gonçalo Lopes, Pedro Vieira, and Jose Paulo Santos. "Monte Carlo simulation of laser beams interaction with the human eye using Geant4." BioMedical Engineering OnLine. 13 (2014): 58. AbstractWebsite
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Lopes, G., D. Tendeiro, J. P. Santos, and P. Vieira. "Monte Carlo Simulation of Radiation through the Human Retina Using Geant4." Vol. 41. Cham: Springer International Publishing, 2014. 431-434. Abstract
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Lopes, G., D. Tendeiro, J. P. Santos, and P. Vieira. "Monte Carlo Simulation of Radiation through the Human Retina Using Geant4." Vol. 41. Cham: Springer International Publishing, 2014. 431-434. Abstract
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Young, M. T., S. Hua, L. Steel, D. Foffa, S. L. Brusatte, S. Thüring, O. Mateus, J. I. Ruiz-Omeñaca, P. Havlik, Y. Lepage, and M. B. De Andrade. "Revision of the Late Jurassic teleosaurid genus Machimosaurus (Crocodylomorpha, Thalattosuchia)." Royal Society Open Science. 1 (2014). Abstract
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2013
Li, Lidong, Patricia S. Lopes, Claudia A. Figueira, Clara S. B. Gomes, M. Teresa Duarte, Vitor Rosa, Christophe Fliedel, Teresa Aviles, and Pedro T. Gomes. "{Cationic and Neutral (Ar-BIAN) Copper( I) Complexes Containing Phosphane and Arsane Ancillary Ligands: Synthesis, Molecular Structure and Catalytic Behaviour in Cycloaddition Reactions of Azides and Alkynes}." {EUROPEAN JOURNAL OF INORGANIC CHEMISTRY} (2013): {1404-1417}. Abstract

{{A series of new cationic and neutral (Ar-BIAN) copper(I) complexes {[}in which Ar-BIAN = bis(aryl)acenaphthenequinonediimine] was synthesised and characterised by elemental analysis, 1D and 2D NMR spectroscopy and single-crystal Xray diffraction. The cationic complexes of the general formula {[}Cu(Ar-BIAN)L-2]BF4 {[}L-2 = (PPh3)(2) (1), dppe (2), dppf (3), (AsPh3)(2) (4); Ar = 4-iPrC(6)H(4) (a), 4-MeOC6H4 (b), 4-NO2C6H4 (c), 2-iPrC(6)H(4) (d), Ph2PCH2CH2PPh2 (dppe), (Ph2PC5H4)(2)Fe (dppf)] were synthesised by reaction of {[}Cu(EPh3)(4)]BF4 (E = P or As) and equimolar amounts of Ar-BIAN ligands, or by reaction of equimolar amounts of {[}Cu(NCMe)(4)]BF4, 4-iPrC(6)H(4)-BIAN (a) and diphosphanes dppe or dppf, in dichloromethane, whereas the neutral complexes of the types {[}CuX(Ar-BIAN)(EPh3)] {[}X = Cl

Almeida, R. M., P. Turano, I. Moura, J. J. Moura, and S. R. Pauleta. "Superoxide reductase: different interaction modes with its two redox partners." ChemBioChem. 14 (2013): 1858-66. AbstractWebsite

Anaerobic organisms have molecular systems to detoxify reactive oxygen species when transiently exposed to oxygen. One of these systems is superoxide reductase, which reduces O2 (.-) to H2 O2 without production of molecular oxygen. In order to complete the reduction of superoxide anion, superoxide reductase requires an electron, delivered by its redox partners, which in Desulfovibrio gigas are rubredoxin and/or desulforedoxin. In this work, we characterized the interaction of Desulfovibrio gigas superoxide reductase with both electron donors by using steady-state kinetics, 2D NMR titrations, and backbone relaxation measurements. The rubredoxin surface involved in the electron transfer complex with superoxide reductase comprises the solvent-exposed hydrophobic residues in the vicinity of its metal center (Cys9, Gly10, Cys42, Gly43, and Ala44), and a Kd of 3 muM at 59 mM ionic strength was estimated by NMR. The ionic strength dependence of superoxide-mediated rubredoxin oxidation by superoxide reductase has a maximum kapp of (37 +/- 12) min(-1) at 157 mM. Relative to the electron donor desulforedoxin, its complex with superoxide reductase was not detected by chemical shift perturbation, though this protein is able to transfer electrons to superoxide reductase with a maximum kapp of (31 +/- 7) min(-1) at an ionic strength of 57 mM. Competition experiments using steady-state kinetics and NMR spectroscopy (backbone relaxation measurements and use of a paramagnetic relaxation enhancement probe) with Fe-desulforedoxin in the presence of (15) N-Zn-rubredoxin showed that these two electron donors compete for the same site on the enzyme surface, as shown in the model structure of the complex generated by using restrained molecular docking calculations. These combined strategies indicate that the two small electron donors bind in different manners, with the desulforedoxin complex being a short lived electron transfer complex or more dynamic, with many equivalent kinetically competent orientations.

Thapper, A., A. C. Rizzi, CD Brondino, A. G. Wedd, R. J. Pais, B. K. Maiti, I. Moura, S. R. Pauleta, and J. J. Moura. "Copper-substituted forms of the wild type and C42A variant of rubredoxin." J Inorg Biochem. 127 (2013): 232-7. AbstractWebsite

In order to gain insights into the interplay between Cu(I) and Cu(II) in sulfur-rich protein environments, the first preparation and characterization of copper-substituted forms of the wild-type rubredoxin (Rd) from Desulfovibrio vulgaris Hildenborough are reported, as well as those of its variant C42A-Rd. The initial products appear to be tetrahedral Cu(I)(S-Cys)n species for the wild type (n=4) and the variant C42A (n=3, with an additional unidentified ligand). These species are unstable to aerial oxidation to products, whose properties are consistent with square planar Cu(II)(S-Cys)n species. These Cu(II) intermediates are susceptible to auto-reduction by ligand S-Cys to produce stable Cu(I) final products. The original Cu(I) center in the wild-type system can be regenerated by reduction, suggesting that the active site can accommodate Cu(I)(S-Cys)2 and Cys-S-S-Cys fragments in the final product. The absence of one S-Cys ligand prevents similar regeneration in the C42A-Rd system. These results emphasize the redox instability of Cu(II)-(S-Cys)n centers.

Neuparth, Nuno, Daniel Aelenei, Iolanda Caires, João Teixeira, João Viegas, Manuela Cano, Paula Leiria-Pinto, and Pedro Martins Environment and Health in Children Day Care Centers - Ambiente e Sa. Eds. Nuno Neuparth, Daniel Aelenei, Iolanda Caires, Joao Paulo Teixeira, Jo Viegas, Manuela Cano, Paula Leiria Pinto, and Pedro Martins. Universidade Nova de Lisboa, 1169-056 Lisboa: Faculdade de Ciências Médicas, 2013.Website
Ana, Baptista, Ferreira Isabel, and Borges João Paulo. "Cellulose-based composite Systems for Biomedical Applications." Biomass-based Biocomposites. Eds. Vijay Kumar Thakur, and Amar Singh Singha. Smithers Rapra, 2013. 47-60. Abstract
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