Curcuma longa L., also known as turmeric, is widely used as a food colorant and has been reported to have antioxidant, anti-inflammatory, anti-mutagenic and anti-cancer properties. The aim of this study was to evaluate the effects of the spray drying on curcuminoid and curcumin contents, antioxidant activity, process yield, the morphology and solubility of the microparticulated solid dispersion containing curcuma extract using a Box Behnken design. The microparticles were spherical in shape, and an increase in outlet temperature from 40 to 80 °C resulted in a significant increase in the yield of microparticles from 16 to 53%. The total curcuminoid content (17.15 to 19.57. mg/g), curcumin content (3.24 to 4.25. mg/g) and antioxidant activity (530.1 to 860.3 μg/mL) were also affected by the spray drying process. The solubility of curcuminoid from C. longa remarkably improved 100-fold in the microparticles, confirming the potential of the ternary solid dispersion technique to improve the dyeing and nutraceutical properties of these compounds. Furthermore, the microparticles were obtained using the spray drying process, can be easily scaled up. © 2011 Elsevier Ltd.

Net Zero-Energy Buildings (NZEBs) have received increased attention in recent years as a result of constant concerns about energy supply constraints, decreasing energy resources, increasing energy costs and the rising impact of greenhouse gases on world climate. Promoting whole building strategies that employ passive measures together with energy efficient systems and technologies using renewable energy became a European political strategy following the publication of the Energy Performance of Buildings Directive recast in May 2010 by the European Parliament and Council. However designing successful NZEBs represents a challenge because the definitions are somewhat generic while assessment methods and monitoring approaches remain under development and the literature is relatively scarce about the best sets of solutions for different typologies and climates likely to deliver an actual and reliable performance in terms of energy balance (consumed vs generated) on a cost-effective basis. Additionally the lessons learned from existing NZEB examples are relatively scarce. The authors of this paper, who are participants in the IEA SHC Task 40-ECBCS Annex 52, "Towards Net Zero Energy Solar Buildings", are willing to share insights from on-going research work on some best practice leading NZEB residential buildings. Although there is no standard approach for designing a Net Zero-Energy Building (there are many different possible combinations of passive and efficient active measures, utility equipment and on-site energy generation technologies able to achieve the net-zero energy performance), a close examination of the chosen strategies and the relative performance indicators of the selected case studies reveal that it is possible to achieve zero-energy performance using well known strategies adjusted so as to balance climate drivendemand for space heating/cooling, lighting, ventilation and other energy uses with climate-driven supply from renewable energy resources.

The aim of this study was to investigate the influence of ultrasound and high-shear mixing on the properties of microparticles obtained by spray congealing. Dispersions containing 10% carbamazepine and 90% carrier Gelucire® 50/13 (w/w) were prepared using magnetic stirring, high-shear mixing, or ultrasound. Each preparation was made using hot-melt mixing spray congealing to obtain the microparticles. All microparticles presented a spherical shape with high encapsulation efficiency (>99%). High-shear mixing and ultrasound promoted a decrease in the size of microparticles (D90) to 62.8 ± 4.1 μm and 64.9 ± 3.3 μm, respectively, while magnetic stirring produced microparticles with a size of 84.1 ± 1.4 μm. The use of ultrasound led to microparticles with increased moisture content as identified through sorption isotherm studies. In addition, rheograms showed distinct rheological behaviour among different dispersion preparations. Therefore, the technique used to prepare dispersions for spray congealing can affect specific characteristics of the microparticles and should be controlled during the preparation. © 2013 Informa UK Ltd. All rights reserved.