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This paper presents an analytical model for the delay propagation of a CMOS Invert circuit. In this paper the Nexp transistor model is considered as a way of granting the accuracy of results in the characterization of submicron CMOS circuits. The analytical model proposed is valid for a ramp input, and takes into account all the operation regions of the transistor and take into account the influence of the gate-to-drain capacitance. An application example considering the use of the model for the evaluation of the delay associated to the CMOS inverter is considered. The validity of the results obtained with analytical model of a 1.8V SMIC018 CMOS inverter is checked against Hspice simulation of the circuit.

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Reactive oxygen species (ROS), when in excess, are among the most deleterious species an organism can deal with. The physiological effects of ROS include amino acid chain cleavage, DNA degradation and lipid oxidation, among others. They can be formed in the cytoplasm in a variety of ways, including autooxidation reactions (FMN- and FAD-containing enzymes) and Fenton reactions as a result of the cytoplasmatic pool of iron ions. The superoxide anion (021, despite its short half-life in solution, is particularly pernicious as it can form other reactive ROS (such as the strong oxidant peroxynitrite) or oxidize and/or reduce cellular components. For strict anaerobic or microaerophilic bacteria it is of particular importance to be able to dispose of ROS in a controlled manner, especially if these organisms are temporarily exposed to air. This review aims to describe the structural characteristics of superoxide reductases (SORs) and mechanistic aspects of biological superoxide anion reduction. SORs can be considered the main class of enzymes behind the oxygen detoxification pathway of anaerobic and microaerophilic bacteria. The geometry of the active site (three classes have been described), the possible electron donors in vivo and the current hypothesis for the catalytic mechanism will be discussed. Some phylogenetic considerations are presented, regarding the primary structure of SORs currently available in genome databases. ((c) Wiley-VCH Verlag GmbH {&} Co. KGaA, 69451 Weinheim, Germany, 2007).

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