Este capítulo pretende contribuir para a análise das principais fontes de ansiedade social causada pela crescente automação em Portugal. O capítulo foi baseado na revisão de literatura internacional e nacional, bem como na análise secundária de dados. Para além disso, durante o projeto DEEP VIEW foram realizadas duas entrevistas não estruturadas a especialistas em relações laborais e 13 entrevistas semiestruturadas a representantes do mundo sindical e de entidades patronais (federações e confederações), em setores particularmente relevantes para as questões associadas ao risco tecnológico.

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The Palace of Knossos, located on the island of Crete, Greece, is one of Europe's most important archaeological sites, serving as a testament to the Minoan civilization. Situated near the Mediterranean Sea, it is in close proximity to the seaport, airport, and industrial areas. Decay products commonly found in historical monuments within or near urban areas, such as black crusts and salt efflorescence, are also prevalent at the Palace of Knossos. To better understand the characteristics of the type of deterioration compounds found on cement in historical reconstruction zones, as well as their possible relationship with factors influencing the deterioration process, a multi-analytical approach was designed for the study of these materials. The results indicate that the black crusts primarily consist of gypsum and carbonaceous matter. However, the efflorescence salts are predominantly composed of thenardite instead of halite, despite the palace's proximity to the coastal area. These results may contribute to ongoing and future maintenance and preservation efforts for the monument.

In this work, both analogue and digital depletion-mode single channel transistor circuits are presented and are simulated using an n-channel IGZO technology with VTH = -0.87V. A logic family is introduced, suppressing the need for an additional voltage level and level restoring circuitry. Furthermore, in the analogue domain, a depletion current mirror topology is presented with demonstrated small current error. Finally, the current mirror is used in the design of an OpAmp, achieving a simulated open-loop gain of 45 dB, CMRR of 58 dB, unity-gain frequency of 444 kHz and a phase margin of 71 degrees.

Sol-gel production of hybrid materials has, to some extent, revolutionised materials’ engineering and the way science and technology perceive the creation of new materials. Despite that, the method presents some limitations that are circumvented by radiation processing. Electron beam irradiation was used to promote synthesis of hybrid structures while using silanol-terminated PDMS, TEOS and TPOZ as precursors. Evaluation of the method’s performance was executed by gel fraction determination, WDXRF and FTIR-ATR. Results showed that, although there is some pre-irradiation reactivity between precursors, radiolysis induces scission on multiple sites of precursor’s structures, which induces hybrid network formation to a greater extent. Characterisation allowed determining electron beam irradiation to be effective in the creation of Si–O–Zr bonds, resulting in the production of a Class II hybrid material.

Reflectins are a family of intrinsically disordered proteins involved in cephalopod camouflage, making them an interesting source for bioinspired optical materials. Understanding reflectin assembly into higher-order structures by standard biophysical methods enables the rational design of new materials, but it is difficult due to their low solubility. To address this challenge, we aim to understand the molecular self-assembly mechanism of reflectin’s basic unit—the protopeptide sequence YMDMSGYQ—as a means to understand reflectin’s assembly phenomena. Protopeptide self-assembly was triggered by different environmental cues, yielding supramolecular hydrogels, and characterized by experimental and theoretical methods. Protopeptide films were also prepared to assess optical properties. Our results support the hypothesis for the protopeptide aggregation model at an atomistic level, led by hydrophilic and hydrophobic interactions mediated by tyrosine residues. Protopeptide-derived films were optically active, presenting diffuse reflectance in the visible region of the light spectrum. Hence, these results contribute to a better understanding of the protopeptide structural assembly, crucial for the design of peptide- and reflectin-based functional materials.

Thyroid diseases affect a considerable portion of the population, with hypothyroidism being one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to treat hypothyroidism and suppress thyroid stimulating hormone secretion in other thyroid diseases. In this work, an attempt to improve T4 solubility is made through the synthesis of ionic liquids (ILs) based on this drug. In this context, [Na][T4] was combined with choline [Ch]+ and 1-(2-hydroxyethyl)-3-methylimidazolium [C2OHMiM]+ cations in order to prepare the desired T4-ILs. All compounds were characterized by NMR, ATR-FTIR, elemental analysis, and DSC, aiming to check their chemical structure, purities, and thermal properties. The serum, water, and PBS solubilities of the T4-ILs were compared to [Na][T4], as well as the permeability assays. It is important to note an improved adsorption capacity, in which no significant cytotoxicity was observed against L929 cells. [C2OHMiM][T4] seems to be a good alternative to the commercial levothyroxine sodium salt with promising bioavailability.

In the current paper, we propose a new three-dimensional strength criterion for rocks expressed in terms of the first principal stress invariant, I1, and the second and third invariants of the deviatoric stress tensor, J2 and J3. The design of this constitutive model conjugates the characteristics of two of the most well-known and widely used criteria in geotechnical engineering: Hoek-Brown and Matsuoka-Nakai. Its material parameters can be calibrated based on conventional axisymmetric compression and extension tests. Experimental polyaxial test data from a dozen different rock types were used to validate the current criterion.

This paper aims at contributing towards a better understanding of the non-uniform elastoplastic torsion mechanism of I-section beams. The particular case of cantilevers subjected to an end torque is analysed, which constitutes a simple yet interesting problem, since the maximum torque is very close to the so-called Merchant upper bound (MUB), with added independent maximum bishear and Saint-Venant torques. Consequently, it turns out that the maximum torque can be significantly higher than that for uniform plastic torsion. Besides the MUB, several solutions are presented and compared, namely (i) a stress resultant-based solution stemming from the warping beam theory differential equilibrium equation and (ii) solutions obtained with several beam finite elements that allow for a coarse/refined description of warping. It is found that all models are in very close agreement in terms of maximum torque (including the MUB) and stress resultants. However, the beam finite elements that allow for bishear, even with a simplified warping function, are further capable of reproducing quite accurately the stress field, as a comparison with a 3D solid finite element solution shows. Although the paper is primarily concerned with the small displacement case, the influence of considering finite rotations is also addressed.