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2013
Lopes, T., and M. P. Amado Modular solution for the construction of sustainable housing at reduced costs. 2º CIHEL 2013. Lisboa, PT: LNEC, ISBN: 978-178-032-381-7, 2013.
Marcelo, Filipa, Catarina Dias, Paulo J. Madeira, Tiago Jorge, Helena M. Florêncio, Javier F. Canada, Eurico J. Cabrita, Jésus Jiménez-Barbero, and Amelia P. Rauter. "Molecular Recognition of Rosmarinic Acid from Salvia sclareoides Extracts by Acetylcholinesterase: A New Binding Site Detected by NMR Spectroscopy." Chemistry: A European Journal. 19 (2013): 6641-6649. AbstractWebsite

Acetylcholinesterase (AChE) inhibition is one of the most currently available therapies for the management of Alzheimer’s disease (AD) symptoms. In this context, NMR spectroscopy binding studies were accomplished to explain the inhibition of AChE activity by Salvia sclareoides extracts. HPLC-MS analyses of the acetone, butanol and water extracts eluted with methanol and acidified water showed that rosmarinic acid is present in all the studied samples and is a major constituent of butanol and water extracts. Moreover, luteolin 4′-O-glucoside, luteolin 3′,7-di-O-glucoside and luteolin 7-O-(6′′-O-acetylglucoside) were identified by MS2 and MS3 data acquired during the LC-MSn runs. Quantification of rosmarinic acid by HPLC with diode-array detection (DAD) showed that the butanol extract is the richest one in this component (134 μg mg−1 extract). Saturation transfer difference (STD) NMR spectroscopy binding experiments of S. sclareoides crude extracts in the presence of AChE in buffer solution determined rosmarinic acid as the only explicit binder for AChE. Furthermore, the binding epitope and the AChE-bound conformation of rosmarinic acid were further elucidated by STD and transferred NOE effect (trNOESY) experiments. As a control, NMR spectroscopy binding experiments were also carried out with pure rosmarinic acid, thus confirming the specific interaction and inhibition of this compound against AChE. The binding site of AChE for rosmarinic acid was also investigated by STD-based competition binding experiments using Donepezil, a drug currently used to treat AD, as a reference. These competition experiments demonstrated that rosmarinic acid does not compete with Donepezil for the same binding site. A 3D model of the molecular complex has been proposed. Therefore, the combination of the NMR spectroscopy based data with molecular modelling has permitted us to detect a new binding site in AChE, which could be used for future drug development.

Rodríguez-Martínez, E. V., R. M. R. Cardoso, and A. D. Egídio dos Reis. "Moments of Dividends and Optimal Expected Dividends in the Erlang(n) dual risk model." ASTIN Colloquium 2013. The Hague, Netherlands 2013.
Sallem, Amin, Pedro Pereira, Mourad Fakhfakh, and Helena Fino. "A Multi-objective Simulation Based Tool: Application to the Design of High Performance LC-VCOs." Technological Innovation for the Internet of Things. Eds. LuisM. Camarinha-Matos, Slavisa Tomic, and Paula Graça. Vol. 394. IFIP Advances in Information and Communication Technology, 394. Portugal: Springer Berlin Heidelberg, 2013. 459-468. Abstract

The continuing size reduction of electronic devices imposes design challenges to optimize the performances of modern electronic systems, such as: wireless services, telecom and mobile computing. Fortunately, those design challenges can be overcome thanks to the development of Electronic Design Automation (EDA) tools. In the analog, mixed signal and radio-frequency (AMS/RF) domains, circuit optimization tools have demonstrated their usefulness in addressing design problems taking into account downscaling technological aspects. Recent advances in EDA have shown that the simulation-based sizing technique is a very interesting solution to the ‘complex’ modelling task in the circuit design optimization problem. In this paper we propose a multi-objective simulation-based optimization tool. A CMOS LC-VCO circuit is presented to show the viability of this tool. The tool is used to generate the Pareto front linking two conflicting objectives, namely the VCO Phase Noise and Power Consumption. The accuracy of the results is checked against HSPICE/RF simulations.

Sallem, A., P. Pereira, M. FahkFahk, and M. H. Fino A Multi-objective Simulation Based Tool: Application to the Design of High Performance LC-VCOs”). 4th IFIP WG 5.5/SOCOLNET Doctoral Conference on Computing, Electrical and Industrial Systems, DoCEIS 2013. Caparica, Portugal: Springer, 2013.
Lourenço, João M., and Eitan Farchi Multicore Software Engineering, Performance, and Tools. Eds. João M. Lourenço, and Eitan Farchi. Vol. 8063. Proceedings of the 2nd International Conference on Multicore Software Engineering, Performance, and Tools, MUSEPAT 2013, Saint Petersburg, Russia, August 19–20, 2013, 8063. Springer Berlin Heidelberg, 2013. Abstract

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Pimenta, Jorge, Aldino Viegas, João Sardinha, Ivo C. Martins, Eurico J. Cabrita, Carlos M. G. A. Fontes, Jose A. M. Prates, and Rosa M. L. N. Pereira. "NMR Solution Structure and SRP54M predicted interaction of the N-Terminal sequence (1-30) of the ovine Doppel protein." Peptides. 49 (2013): 32-40. AbstractWebsite

Prion protein (PrPC) biosynthesis involves a multi-step process that includes translation and post-translational modifications. While PrP has been widely investigated, for the homolog Doppel (Dpl), limited knowledge is available. In this study, we focused on a vital step of eukaryotic protein biosynthesis: targeting by the signal recognition particle (SRP). Taking the ovine Dpl (OvDpl(1-30)) peptide as a template, we studied its behavior in two different hydrophobic environments using CD and NMR spectroscopy. In both trifluoroethanol (TFE) and dihexanoyl-sn-glycero-3-phosphatidylcholine (DHPC), the OvDpl(1-30) peptide revealed to fold in an alpha-helical conformation with a well-defined central region extending from residue Cys8 until Ser22. The NMR structure was subsequently included in a computational docking complex with the conserved M-domain of SRP54 protein (SRP54M), and further compared with the N-terminal structures of mouse Dpl and bovine PrPC proteins. This allowed the determination of (i) common predicted N-terminal/SRP54M polar contacts (Asp331, Gln335, Glu365 and Lys432) and (ii) different N–C orientations between prion and Dpl peptides at the SRP54M hydrophobic groove, that are in agreement with each peptide electrostatic potential. Together, these findings provide new insights into the biosynthesis of prion-like proteins. Besides they also show the role of protein conformational switches in signalization toward the endoplasmic membrane, a key event of major significance in the cell cycle. They are thus of general applicability to the study of the biological function of prion-like as well as other proteins.

Biscaia, Hugo C., Carlos Chastre, and Manuel A. G. Silva. "Nonlinear numerical analysis of the debonding failure process of FRP-to-concrete interfaces." Composites Part B: Engineering. 50 (2013): 210-223. AbstractWebsite

The paper analyses numerical solutions for the process leading to debonding failure of fiber reinforced polymers (FRP)-to-concrete interfaces in shear tests with the FRP plate subjected to a tensile load at one end. Any realistic local nonlinear bond-slip law can be used in the numerical analysis proposed in the present study. However, only a Popovics’ type expression is employed in the numerical process due to its use in different studies found in the literature. Effective bond length (Leff) is discussed and an expression depending on the Popovics’ constant (nP) is proposed to calculate it. Assuming a fracture in pure Mode II, the debonding process is analyzed in detail and distributions of bond stresses and strains in the FRP plate along the interface are presented. The load-displacement behaviour is also presented and the influence of the local bond-slip law on the debonding process is discussed.

N.J.Ford, M. L. Morgado, and M. Rebelo Nonpolynomial approximation of solutions to delay fractional differential equations. Proceedings of the 13th International Conference on Computational and Mathematical Methods in Science and Engineering, CMMSE2013. Almería , Spain.: ISBN:978-84-616-2723-3, 2013.
Ford, Neville J., Luísa M. Morgado, and Magda Rebelo. "Nonpolynomial collocation approximation of solutions to fractional differential equation." Fractional Calculus and Applied Analysis. 16.4 (2013): 874-891.
Ferreira, Adelino, Fábio Simões, Rui Micaelo, and Cássio Paiva Novo método de dimensionamento de pavimentos da AASHTO – aplicação a Portugal. 17.º Congreso Ibero-Latinoamericano del Asfalto. Antigua, Guatemala, 2013.
Ferreira, Adelino, Fábio Simões, Rui Micaelo, and Cássio Paiva Novo método de dimensionamento de pavimentos rodoviários da AASHTO – Aplicação a Portugal. 19ª Reunião de Pavimentação Urbana. Cuiabá, Brasil, 2013.
Campos-Rebelo, Rogério, Anikó Costa, and Luís Gomes. "On Structuring Events for {IOPT} Net Models." Technological Innovation for the Internet of Things - 4th {IFIP} {WG} 5.5/SOCOLNET Doctoral Conference on Computing, Electrical and Industrial Systems, DoCEIS 2013, Costa de Caparica, Portugal, April 15-17, 2013. Proceedings. 2013. 229-238. Abstract

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Vale, Tiago M., Ricardo J. Dias, and João M. Lourenço. "On the Relevance of Total-Order Broadcast Implementations in Replicated Software Transactional Memories." Multicore Software Engineering, Performance, and Tools. Eds. João M. Lourenço, and Eitan Farchi. Vol. 8063. Lecture Notes in Computer Science, 8063. Springer Berlin Heidelberg, 2013. 49-60. Abstractmusepat13-vale.pdf

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Fino, M. H., and F. Coito On the use of compact modeling for RF/analog design automation. 20th International Conference in Mixed Design of Integrated Circuits and Systems (MIXDES). Poland: IEEE, 2013.
Rodrigues, Paula, Cristiana J. Silva, and Delfim F. M. Torres Optimal control strategies for reducing the number of active infected individuals with tuberculosis. SIAM Conference on Control and Its Applications (CT13). San Diego, California, USA, 2013.
Grade, Nuno, Lúcio Ferrão, and João Costa Seco Optimizing Data Queries Over Heterogeneous Sources. INForum 2013. Évora, 2013.inforum2013.pdf
Moniz, António Brandão Organizational concepts and interaction between humans and robots in industrial environments. IROS 2013 "DRHE 2013 Dependable Robots in Human Environments". Tokyo: AIST - National Institute of Advanced Industrial Science and Technology, 2013. Abstract

This paper is discussing the intuitive interaction with robotic systems and the conceptualisation connected with known organisational problems. In particular, the focus will be on the manufacturing industry with respect to its social dimension. One of the aims is to identify relevant research questions about the possibility of development of safer robot systems in closer human-machine intuitive interaction systems at the manufacturing shop-floor level. We try to contribute to minimize the cognitive and perceptual workload for robot operators in complex working systems. In particular that will be highly relevant when more different robots with different roles and produced by different companies or designers are to be used in the manufacturing industry to a larger extent. The social sciences approach to such technology assessment is of high relevance to understand the dimensions of the intuitive interaction concept.

Paulos, Margarida, and António Brandão Moniz. "Os trabalhadores do conhecimento num setor tradicional: O caso dos designers do vestuário." Sociologia Problemas e Práticas. 2013.72 (2013): 103-122.
Mannion, Philip D., Paul Upchurch, Rosie N. Barnes, and Octávio Mateus. "Osteology of the Late Jurassic Portuguese sauropod dinosaur Lusotitan atalaiensis (Macronaria) and the evolutionary history of basal titanosauriforms." Zoological Journal of the Linnean Society. 168 (2013): 98-206. Abstractmannion_et_al_2013_sauropod_lusotitan_portugal.pdfWebsite

Titanosauriforms represent a diverse and globally distributed clade of neosauropod dinosaurs, but their inter-relationships remain poorly understood. Here we redescribe Lusotitan atalaiensis from the Late Jurassic Lourinhã Formation of Portugal, a taxon previously referred to Brachiosaurus. The lectotype includes cervical, dorsal, and caudal vertebrae, and elements from the forelimb, hindlimb, and pelvic girdle. Lusotitan is a valid taxon and can be diagnosed by six autapomorphies, including the presence of elongate postzygapophyses that project well beyond the posterior margin of the neural arch in anterior-to-middle caudal vertebrae. A new phylogenetic analysis, focused on elucidating the evolutionary relationships of basal titanosauriforms, is presented, comprising 63 taxa scored for 279 characters. Many of these characters are heavily revised or novel to our study, and a number of ingroup taxa have never previously been incorporated into a phylogenetic analysis. We treated quantitative characters as discrete and continuous data in two parallel analyses, and explored the effect of implied weighting. Although we recovered monophyletic brachiosaurid and somphospondylan sister clades within Titanosauriformes, their compositions were affected by alternative treatments of quantitative data and, especially, by the weighting of such data. This suggests that the treatment of quantitative data is important and the wrong decisions might lead to incorrect tree topologies. In particular, the diversity of Titanosauria was greatly increased by the use of implied weights. Our results support the generic separation of the contemporaneous taxa Brachiosaurus, Giraffatitan, and Lusotitan, with the latter recovered as either a brachiosaurid or the sister taxon to Titanosauriformes. Although Janenschia was recovered as a basal macronarian, outside Titanosauria, the sympatric Australodocus provides body fossil evidence for the pre-Cretaceous origin of titanosaurs. We recovered evidence for a sauropod with close affinities to the Chinese taxon Mamenchisaurus in the Late Jurassic Tendaguru beds of Africa, and present new information demonstrating the wider distribution of caudal pneumaticity within Titanosauria. The earliest known titanosauriform body fossils are from the late Oxfordian (Late Jurassic), although trackway evidence indicates a Middle Jurassic origin. Diversity increased throughout the Late Jurassic, and titanosauriforms did not undergo a severe extinction across the Jurassic/Cretaceous boundary, in contrast to diplodocids and non-neosauropods. Titanosauriform diversity increased in the Barremian and Aptian–Albian as a result of radiations of derived somphospondylans and lithostrotians, respectively, but there was a severe drop (up to 40%) in species numbers at, or near, the Albian/Cenomanian boundary, representing a faunal turnover whereby basal titanosauriforms were replaced by derived titanosaurs, although this transition occurred in a spatiotemporally staggered fashion.

Baltazar, LG, F. M. A. Henriques, F. Jorne, and M. T. Cidade. "Performance improvement of hydraulic lime based grouts for masonry consolidation: An experimental study." Structural Studies, Repairs and Maintenance of Heritage Architecture XIII, WIT Transactions on the Built Environment. Southampton: WIT Press, 2013. 417-430.
Amado, M. P., and F. Poggi Planning for solar smart cities. CISBAT 13. Lausanne, CH: the Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne ISBN: 978-2-8399-1280-8, 2013.
Ramos, Tania Rodrigues Pereira, Maria Isabel Gomes, and Ana Paula Barbosa-póvoa. "Planning Waste Cooking Oil Collection Systems." Waste Management. 33.8 (2013): 1691-1703. AbstractWebsite

This research has been motivated by a real-life problem of a waste cooking oil collection system characterized by the existence of multiple depots with an outsourced vehicle fleet, where the collection routes have to be plan. The routing problem addressed allows open routes between depots, i.e., all routes start at one depot but can end at the same or at a different one, depending on what minimizes the objective function considered. Such problem is referred as a Multi-Depot Vehicle Routing Problem with Mixed Closed and Open Inter-Depot Routes and is, in this paper, modeled through a Mixed Integer Linear Programming (MILP) formulation where capacity and duration constraints are taken into account. The model developed is applied to the real case study providing, as final results, the vehicle routes planning where a decrease of 13% on mileage and 11% on fleet hiring cost are achieved, when comparing with the current company solution.

Salminen, J., J. Dinis, and O. Mateus Preliminary magnetostratigraphy for Jurassic/Cretaceous transition in Porto da Calada, Portugal. In: Veikkolainen, T., Suhonen, K., Näränen, J., Kauristie, K., and Kaasalainen, S. (eds.). XXVI Geofysiikan päivät,. May 21-22 2013 in Helsinki, 2013.salminen.johanna_gfp2013_portugal_preliminary_magnetostratigraphy_for_jurassic_cretaceous_transition_in.pdf