Ethylcellulose/methylcellulose blends were produced using different precipitation techniques and impregnated with naproxen, a non-steroidal anti-inflammatory drug (NSAID). Solvent-evaporation technique was used not only for the preparation of ethylcellulose/methylcellulose microspheres but also to encapsulate naproxen. Supercritical fluid (SCF) impregnation was also performed to prepare naproxen loaded microspheres. The microspheres, impregnated by the SCF technique, were prepared both by solvent-evaporation and by a supercritical antisolvent (SAS) process. In vitro release profiles at pH 7.4 and 1.2, of naproxen-loaded microspheres were evaluated and the results were modelled Fick's law of diffusion and Power law. Miscrospheres prepared by supercritical antisolvent have a higher loading capacity and present a slower release profile. The systems studied present a release mechanism controlled by drug diffusion which complies Fick's law of diffusion. © 2005 Elsevier B.V. All rights reserved.

The supercritical antisolvent (SAS) technique was used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 $μ$m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40°C and 80 bar. © 2006 Elsevier B.V. All rights reserved.

Mass sorption and diffusion coefficients in one acrylate biocompatible copolymer contacted with supercritical (sc) carbon dioxide are reported. Equilibrium solubility of dense carbon dioxide in poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacr ylate) (P(MMA-EHA-EGDMA)) was studied by a gravimetric method in a temperature range from 308 to 323 K and a pressure range from 10.0 to 20.0 MPa. The cross-linked copolymer presented Fickian behavior and Fick's diffusion model was applied to determine the amount of carbon dioxide present and the diffusion coefficients. Diffusion coefficients for the sorption under supercritical conditions and desorption at ambient conditions were determined and compared. Samples of P(MMA-EHA-EGDMA) with different thickness were used for comparison of the maximum sorption degree. Polymerization conditions were also varied in order to evaluate the influence of the molecular weight of the copolymer in the CO2 sorption process. To investigate the possibility of impregnating this acrylate copolymer with an anti-inflammatory drug, a preliminary experiment was performed. © 2005 Elsevier B.V. All rights reserved.

Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems. © 2006 Elsevier B.V. All rights reserved.

The seismic retrofit of reinforced concrete columns with FRP jackets has received a considerable increment in recent years due the high strength-weight and stiffness-weight ratios of FRP compared to other materials. The FRP outer shell also contributes to prevent or delay environmental degradation of the concrete and corrosion of the steel reinforcement. An experimental program conducted in order to analyze the behavior of reinforced concrete columns jacketed with FRP composites or repaired with polymeric concrete and subjected to axial compression and cyclic horizontal loads is described. The dimensions of the cylindrical columns were 1500 mm height by 250 mm diameter. The influence of various parameters on the response, including the type of confining material and the number of FRP layers, is reported. The results of the tests are shown and interpreted.

Flexibilisation and complexification of working places, due to the information technologies, requires an holistic approach to the labour reality, in an integrative and wide perspective of different scenarios and operational contexts. Such new changes implies the development of new personal and professional features that are beyond the restrict frame of the autonomous, discrete and specialised work. The knowledge needed for the work in organisations can be searched in the working processes modelling. And that can be a constructive basis of a “knowledge map”. Thus, are described the activities of different working processes, and that induces the emergence of a group of informations (indicators) necessary to the construction of each competence that supports the execution of those processes. This action even allows the existence of possible gaps in the strategies of long-life education and training. They assume more and more a critical support to the need of updating and maintenance of professional competences. How to identify and operationalise the professional competences in a working complex system is one of the main issues in this paper. The case study presented in this paper is refered to the air traffic control and it presents the methodology used for the identification and validation of a group of structuring professional competencies that are evident in a complex working system.

The paper reports experimental and numerical simulation of ballistic impact problems on thin composite laminated plates reinforced with Kevlar 29. Ballistic impact was imparted with simulated fragments designed in accordance with STANAG-2920 on plates of different thickness. Numerical modelling was developed and used to obtain an estimate for the limit perforation velocity V50 and simulate failure modes and damage. Computations were carried out using a commercial code based on nite differences and values obtained are compared with the experimental data to evaluate the performance of the simulation. Good correlation between computational simulation and experimental results was achieved, both in terms of deformation and damage of the laminates. Future work is advanced to include the interposition of an outer ceramic layer as well as examining the influence of dry-wet and temperature cycles on the mechanical strength of the plates and their temporal evolution under accelerated ageing.

A general model for the design and planning of closed-loop supply chains is proposed. The model is both strategic and tactical in nature, containing two levels of decisions: the location of facilities and the planning of production, storage and distribution. Its mathematical formulation is solved using a standard Branch and Bound technique. The model applicability and accuracy are studied on a modified version of an already published case study.

This thesis deals with the analysis of the behaviour of retrofitting reinforced concrete circular columns with FRP materials which were subjected either to axial cyclic compression or axial compression and alternated cyclic horizontal loads. The choice of this topic derived from the need to investigate the behaviour of the strengthening of reinforced concrete columns to seismic actions, especially with new materials such as carbon and glass fibres or polymeric mortars. Another reason for such choice is linked to the strong seismicity of the Portuguese territory.
It has been verified that confined concrete columns with FRP jackets have their resistance and ductility highly increased as these considerably reduce the columns transversal deformation, thus preventing the buckling of longitudinal reinforcement. There has been an increasing use of FRP composites in the strengthening of structures, mainly with GFRP (Glass Fibre Reinforced Plastics) or CFRP (Carbon Fibre Reinforced Plastics). This is due to their attractive characteristics such as high resistance to corrosion, lowratio for weight/strength, moldability, easy application and the fact that there is no need of support structures.
Forty-five experimental tests were carried out, dealing with retrofitting reinforced concrete columns with axial monotonic or cyclic compression reinforced with FRP composites. The column height of 750 mm was maintained in order to evaluate the influence of several parameters in its behaviour: the column geometry (change in its diameter), the type of column (plain or reinforced concrete), transversal reinforcement ratio of concrete columns, the type of external confinement with FRP (C or GFRP), the number of FRP layers and the type of axial loading (monotonic or cyclic).
Twelve additional experimental tests were conducted in order to analyse the behaviour of reinforced concrete columns jacketed with FRP composites and subjected to axial cyclic compression and alternated cyclic horizontal loads. The columns’ dimension was maintained (1500 mm height by 250 mm diameter) and the models were subjected to a series of cyclic and alternated loadings. This enabled the study of the various parameters’ influence in their behaviour such as the type of FRP confinement, the number of FRP layers, the level of axial loading, the jacket’s height or the strengthening of the plastic hinge by replacing the cover concrete with polymeric mortar.
Based on the numerical models presented and experimental analysis carried out, models were proposed and developed to simulate the behaviour of columns jacketed with FRP composites.

If H is a family of graphs, then an H-decomposition of a graph G is a partition of the edges of G each element of which induces a copy of a graph in G.
This paper addresses the problem of finding the number φ(n,H), the smallest number k such that every graph on n vertices has an H-decomposition with at most k elements. φ(n,H) is found in the cases when H={K2,C5}; when H={K2,C5+e}, where e is a chord of the C5; when H={K2,K4−e}; and when H={K2,K3+e}, where e is a pendant edge added to one vertex in the K3.

A multi-product model for the design of global supply chains with reverse flows is proposed. Two levels of decisions are considered, one strategic and one tactical. The first is modelled through a macro perspective of time where the determination of the network structure and flows is accomplished. At tactical level, a micro perspective of time is considered, where production planning and inventory management are addressed in detail. A mixed integer linear programming formulation is developed which is solved with standard Branch and Bound techniques. The model accuracy and suitability are studied using a case study.

Much attention is currently given to the study of supply chains. Most studies are, however, only concerned with forward chains, rendering reverse chains a field insufficiently covered. Few optimization models addressing either the design of reverse networks or the simultaneous design of forward and reverse networks have been presented. We propose a MILP model for the design and planning of an integrated forward and reverse chain. While minimizing cost, the network structure is defined simultaneously with production and storage planning. Dynamic aspects are accounted for using a two-time scale, fully interconnected structure, where at a macro time the network design is performed and at a micro time the planning is optimised. The deterministic model is extended and a scenario approach is applied to account for uncertainties in demand and return of products. A case study is solved and a common structure to all scenarios is obtained, while scenario dependent policies are defined for distribution, production and storage. The model generality is corroborated with good performance results.

This paper is mainly focused on the characterisation of a glass material (GM) obtained from the thermal treatment of a bottom ash (BA) produced at the Municipal Solid Waste (MSW) incineration plant of Valorsul. By melting the BA at 1400ºC during 2 hours, and without using any chemical additives, a homogeneous black-coloured glass was obtained. The thermal and mechanical properties of this glass were characterised. The thermal expansion coefficient, measured by dilatometry, was 9-10 x 10-6 per ºC and the modulus of rupture, determined by four-point bending test, was 75±6 MPa, which are similar values to those exhibited by commercial soda-lime-silica glasses used in structural applications. The chemical and the ecotoxicological leaching behaviour of the GM were also analysed. The GM was submitted to a leaching procedure composed of 15 sequential extraction cycles. A liquid/solid (L/S) ratio of 2 l/kg was applied in each cycle. The leachates were filtered through a membrane of PTFE (porosity: 0.45 µm). The filtered leachates were characterised for different chemical parameters and for an ecotoxicological indicator (bacterium Vibrio fischeri). The GM was also submitted to a microwave acidic digestion for the assessment of the total metal content. The crude BA was also submitted to the same experimental procedures. The GM showed levels of chemical emission and ecotoxicity for V. fischeri much lower than those determined for the crude BA. Similar characterisation studies will be pursued with the glass-ceramics produced by adequate thermal treatment of the glass, in order to investigate the effect of the crystallization on the final properties.

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