{Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation}

Citation:
Duarte AR, Gordillo MD, Cardoso MM, Simplício AL, Duarte CM. {Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation}. International Journal of Pharmaceutics. 2006;311:50-4. copy at https://docentes.fct.unl.pt/ard08968/publications/preparation-ethyl-cellulosemethyl-cellulose-blends-supercritical-antisolvent-p

Abstract:

The supercritical antisolvent (SAS) technique was used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 $μ$m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40°C and 80 bar. © 2006 Elsevier B.V. All rights reserved.

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