Overexpression of the Thomsen-Friedenreich (TF) antigen in cell membrane proteins occurs in 90% of adenocarcinomas. Additionally, the binding of the TF-antigen to human galectin-3 (Gal-3), also frequently overexpressed in malignancy, promotes cancer progression and metastasis. In this context, structures that interfere with this specific interaction display the potential to prevent cancer metastasis. Herein, a multidisciplinary approach, combining the optimized synthesis of a TF-antigen mimetic with NMR, X-ray crystallography methods and isothermal titration calorimetry assays has been employed to unravel the molecular structural details that govern the Gal-3/TF-mimetic interaction. The TF-mimetic presents a binding affinity for Gal-3 similar to the TF-natural antigen and retains the binding epitope and the bioactive conformation observed for the native antigen. Furthermore, from a thermodynamic perspective a decrease in the enthalpic contribution was observed for the Gal-3/TF-mimetic complex, however this behaviour is compensated by a favourable entropy gain. From a structural perspective, these results establish our TF-mimetic as a scaffold to design multivalent solutions to potentially interfere with Gal-3 aberrant interactions and likely be used to hamper Gal-3-mediated cancer cells adhesion and metastasis.

Pseudo-cyclic and cyclic loading were applied to CFRP-to-steel bonded joints built with two different CFRP laminates. In this paper, the strength capacity and bond-slip curves are presented and compared. The modes of failure are also described and associated with the types of material used, and the observed performances are correlated. The analysis of the results showed a threshold value for loading and amplitude level, below which the cyclic loading caused no detectable damage. For cycles above that limit, the region of the joints around the loaded end presented degradation reflected on the bond-slip stiffness and on the increase of residual deformation. It was found that the normalized dissipated energies either obtained from the bond-slip relationship or from the load-slip response had the same trend. The experimental data allowed also to establish a relationship between the damage developed within the interface and the normalized slip. A preliminary estimate of fatigue limit based on those data is suggested.

Purpose The antique structures are part of the inheritance that our elders left, being important to preserve their memories. It is important to preserve, rehabilitate and restore the historic buildings protecting the cultural patrimony, attending to the actual comfort and habitability requirements. It is necessary to study the behaviour of the various elements that compose antique structures (masonry and wood) in order to develop assessment measures according to the characteristics of the original materials. The paper aims to discuss these issues. Design/methodology/approach An experimental campaign to characterize the mechanical behaviour of the wood of the roof of the �sequeiro� of �Quinta Lobeira de Cima�, a building from the twentieth century located in Minho, was carried out. The tested wood specimens are from two different species: chestnut and oak. Compression, tension and static flexion tests according to parallel to the grain direction were performed. Other parameters, such as density, moisture content and longitudinal modulus of elasticity in compression and in tension, were also obtained. The measurement of displacements was made with Digital Image Correlation (DIC). Findings The results of this study show the similarity between experimental and empirical values for the studied woods species. Originality/value This original study aimed at characterizing the mechanical properties using DIC of wood of the roof of the �sequeiro� of �Quinta Lobeira de Cima�, a building from the twentieth century located in Minho (Portugal). This study is part of master thesis of Jo�o Martins, an original research work.

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The cyclic shift graph of a monoid is the graph whose vertices are the elements of the monoid and whose edges connect elements that are cyclic shift related. The Patience Sorting algorithm admits two generalizations to words, from which two kinds of monoids arise, the $\belr$ monoid and the $\bell$ (also known as Bell) monoid. Like other monoids arising from combinatorial objects such as the plactic and the sylvester, the connected components of the cyclic shift graph of the $\belr$ monoid consists of elements that have the same number of each of its composing symbols. In this paper, with the aid of the computational tool SageMath, we study the diameter of the connected components from the cyclic shift graph of the $\belr$ monoid.

Within the theory of monoids, the cyclic shift relation, among other relations, generalizes the relation of conjugacy for groups. We examine several of these relations for both the $\belr$ and the $\bell$ monoids.