Transactional memory (TM) is consistently making its way into mainstream programming, being already deployed by some of the major CPU manufacturers and in several reference compilers. To cope with requirements such as scalability and dependability, recent proposals explore the combination of TM with data replication, bringing TM to distributed environments - conceiving distributed transactional memory (DTM). However, current DTM frameworks support only full data replication. They provide the best possible level of tolerance to data loss, but limit the system's total storage capacity to the capacity of the node with fewer resources, and require coordination among all the system's nodes, an approach bound to hamper scalability in large scale systems. In this context, a partial data replication strategy can help to lessen these shortcomings. Each node replicates only a subset of the system's dataset, an approach that aims at combining the best of data distribution and full replication, while trying to attenuate their disadvantages. The key idea is to allow the dataset to be distributed among the participating nodes and to decrease the number of nodes that have to participate in a transaction's confirmation, as any given transaction only has to be confirmed by the nodes that replicate the data items in its read and write sets. By distributing the data and reducing the coordination cost among nodes, partial data replication leverages the system's scalability. Although this strategy has already been explored by the distributed databases research field, it is yet to be addressed in the context of (D)TM. More specifically, partial data replication has been broadly applied in key-value stores, and even though these work on in-memory data and support transactions, they present significant differences when compared with DTM systems for general purpose programming languages. To this extent, we propose PARdstm, to the best of our knowledge, the first DTM framework to include support for partial data replication. As such, the contributions of this work are: a reasoning on how partial data replication shall be supported in general purpose programming languages (Java, in particular), and a modular software framework that embeds such principles to provide a highly expressive and non-intrusive programming API. Initial experimental results give evidence that our approach may enhance scalability in large scale systems, when compared to full data replication. An ongoing comprehensive study will allow us to assess in which contexts of use (workloads, number of nodes, etc.) partial data replication may be an effective alternative.

© 2014 American Institute of Chemical Engineers. Significance: Natural deep eutectic solvents (NADES) are defined as a mixture of two or more solid or liquid components, which at a particular composition present a high melting point depression becoming liquids at room temperature. NADES are constituted by natural molecules and fully represent the green chemistry principles. For these reasons, the authors believe that the submitted manuscript is a highly valuable contribution to the field of green chemistry and chemical engineering. For the first time, the possibility to use NADES as enhancers of supercritical fluid technology is revealed.

The design and production of structures with nanometer-sized polymer films based on layer-by-layer (LbL) are of particular interest for tissue engineering since they allow the precise control of physical and biochemical cues of implantable devices. In this work, a method is developed for the preparation of nanostructured hollow multilayers tubes combining LbL and template leaching. The aim is to produce hollow tubes based on polyelectrolyte multilayer films with tuned physical-chemical properties and study their effects on cell behavior. The final tubular structures are characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), microscopy, swelling, and mechanical tests, including dynamic mechanical analysis (DMA) in physiological simulated conditions. It is found that more robust films could be produced upon chemical cross-linking with genipin. In particular, the mechanical properties confirms the viscoelastic properties and a storage and young modulus about two times higher. The water uptake decreases from about 390{%} to 110{%} after the cross-linking. The biological performance is assessed in terms of cell adhesion, viability, and proliferation. The results obtained with the cross-linked tubes demonstrate that these are more suitable structures for cell adhesion and spreading. The results suggest the potential of these structures to boost the development of innovative tubular structures for tissue engineering approaches.

Green technology actively seeks new solvents to replace common organic solvents that present inherent toxicity and have high volatility, leading to evaporation of volatile organic compounds to the atmosphere. Over the past two decades, ionic liquids (ILs) have gained enormous attention from the scientific community, and the number of reported articles in the literature has grown exponentially. Nevertheless, IL "greenness" is often challenged, mainly due to their poor biodegradability, biocompatibility, and sustainability. An alternative to ILs are deep eutectic solvents (DES). Deep eutectic solvents are defined as a mixture of two or more components, which may be solid or liquid and that at a particular composition present a high melting point depression becoming liquids at room temperature. When the compounds that constitute the DES are primary metabolites, namely, aminoacids, organic acids, sugars, or choline derivatives, the DES are so called natural deep eutectic solvents (NADES). NADES fully represent green chemistry principles. Can natural deep eutectic solvents be foreseen as the next generation solvents and can a similar path to ionic liquids be outlined? The current state of the art concerning the advances made on these solvents in the past few years is reviewed in this paper, which is more than an overview on the different applications for which they have been suggested, particularly, biocatalysis, electrochemistry, and extraction of new data. Citotoxicity of different NADES was evaluated and compared to conventional imidazolium-based ionic liquids, and hints at the extraction of phenolic compounds from green coffee beans and on the foaming effect of NADES are revealed. Future perspectives on the major directions toward which the research on NADES is envisaged are here discussed, and these comprised undoubtedly a wide range of chemically related subjects. © 2014 American Chemical Society.