Cunha, Jácome, João Paulo Fernandes, Jorge Mendes, and João Saraiva. "
Embedding and Evolution of Spreadsheet Models in Spreadsheet Systems."
Proceedings of the 2011 IEEE Symposium on Visual Languages and Human-Centric Computing. VLHCC '11. Washington, DC, USA: IEEE Computer Society, 2011. 186-201.
AbstractThis paper describes the embedding of ClassSheet models in spreadsheet systems. ClassSheet models are well-known and describe the business logic of spreadsheet data. We embed this domain specific model representation on the (general purpose) spreadsheet system it models. By defining such an embedding, we provide end users a model-driven engineering spreadsheet developing environment. End users can interact with both the model and the spreadsheet data in the same environment. Moreover, we use advanced techniques to evolve spreadsheets and models and to have them synchronized. In this paper we present our work on extending a widely used spreadsheet system with such a model-driven spreadsheet engineering environment.
Duarte, Filipe J. S., Snezhana M. Bakalova, Eurico J. Cabrita, and Gil A. Santos. "
Lewis Acid Catalyzed Reactions of Chiral Imidazolidinones and Oxazolidinones: Insights on the Role of the Catalyst."
Journal of Organic Chemistry. 76.17 (2011): 6997-7004.
AbstractThe mechanism proposed by Evans to justify the selectivity obtained in Lewis acid catalyzed Diels-Alder reactions of cyclopentadiene with acyloxazolidinones has been generalized and used in the rationalization of selectivities obtained in many other systems. However, we recently proposed an alternative mechanism, on the basis of open-chain mono- and bicomplexes, that avoids the need for chelates and explains the selectivity obtained by Evans. In this manuscript we apply our proposal to the catalyzed conjugated addition of amines to acylimidazolidinones, reported by Cardillo, and we clearly show that aluminum chelates are not involved in the reaction, as they induce no selectivity, while Cardillo observed high experimental selectivities. Our data equally show that bicomplexes with carbonyl parallel orientation, proposed by Cardillo to justify the experimental selectivity with nonchelating Lewis acids, indeed induce the opposite selectivity and have also to be dismissed. On the other hand, our mechanistic proposal allows for the full rationalization of the data obtained by Cardillo with aluminum, boron, or zinc Lewis acids and supports our previous proposal on DA cycloadditions of dienes to Evans chiral auxiliary derivatives.
Baptista, Pedro V., Gonçalo Doria, Pedro Quaresma, Miguel Cavadas, Cristina S. Neves, Inês Gomes, Peter Eaton, Eulália Pereira, and Ricardo Franco. "
Nanoparticles in Molecular Diagnostics."
Progress in Molecular Biology and Translational Science: Nanoparticles in Translational Science and Medicine. Elsevier, 2011. 427-488.