Abstract Several analyses of diversity through geological time use global, synoptic databases, and this practice often makes it difficult to distinguish true signals in changing diversity from regional-scale sampling and/or geological artefacts. Here we investigate how echinoid diversity changed through the Mesozoic of the Lusitanian basin in Portugal based on a comprehensive, revised database, and seek to distinguish biological signal from geological or environmental constraints. The observed diversity pattern is far from having a defined trend, showing many fluctuations that appear to be linked with gaps in the geological record. This study revealed that, independently of the method used, whether correlation tests or model fitting, the diversity signal is not completely explained by the studied sampling proxies. Among the different proxies, marine facies variation in combination with outcrop area best explains the palaeodiversity curve.

http://docentes.fct.unl.pt/lblm/files/jbic-2015-20-181.pdf

http://docentes.fct.unl.pt/lblm/files/jbic-2015-20-287.pdf

http://docentes.fct.unl.pt/lblm/files/biochemistry-2015-54-685.pdf

http://docentes.fct.unl.pt/lblm/files/jbic-2015-20-403_1.pdf

If the question is whether there is a parliamentary technology assessment (PTA) unit in Portugal or Spain, the clear answer is that there is still no such unit at the central state level at the present time, neither in Portugal nor in Spain. The question then has to be modified addressing previous and current efforts to establish PTA and the current framework conditions and opportunities. Practices of PTA are framed here as a democratic innovation in the context of changes in representative democracies. Against this backdrop, the efforts and opportunities to establish PTA in Spain and Portugal are studied. By sketching these developments and outlining the opportunities in these countries, our aim is to contribute to the debate about the likelihood of a new wave of PTA in Europe (Hennen/Nierling 2014).

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Theropods form a taxonomically and morphologically diverse group of dinosaurs that include extant birds. Inferred relationships between theropod clades are complex and have changed dramatically over the past thirty years with the emergence of cladistic techniques. Here, we present a brief historical perspective of theropod discoveries and classification, as well as an overview on the current systematics of non-avian theropods. The first scientifically recorded theropod remains dating back to the 17th and 18th centuries come from the Middle Jurassic of Oxfordshire and most likely belong to the megalosaurid Megalosaurus. The latter was the first theropod genus to be named in 1824, and subsequent theropod material found before 1850 can all be referred to megalosauroids. In the fifty years from 1856 to 1906, theropod remains were reported from all continents but Antarctica. The clade Theropoda was erected by Othniel Charles Marsh in 1881, and in its current usage corresponds to an intricate ladder-like organization of ‘family’ to ‘superfamily’ level clades. The earliest definitive theropods come from the Carnian of Argentina, and coelophysoids form the first significant theropod radiation from the Late Triassic to their extinction in the Early Jurassic. Most subsequent theropod clades such as ceratosaurs, allosauroids, tyrannosauroids, ornithomimosaurs, therizinosaurs, oviraptorosaurs, dromaeosaurids, and troodontids persisted until the end of the Cretaceous, though the megalosauroid clade did not extend into the Maastrichtian. Current debates are focused on the monophyly of deinonychosaurs, the position of dilophosaurids within coelophysoids, and megaraptorans among neovenatorids. Some recent analyses have suggested a placement of dilophosaurids outside Coelophysoidea, Megaraptora within Tyrannosauroidea, and a paraphyletic Deinonychosauria with troodontids placed more closely to avialans than dromaeosaurids.

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This paper studies complete rewriting systems and biautomaticity for three interesting classes of finite-rank homogeneous monoids: Chinese monoids, hypoplactic monoids, and sylvester monoids. For Chinese monoids, we first give new presentations via finite complete rewriting systems, using more lucid constructions and proofs than those given independently by Chen & Qui and Güzel Karpuz; we then construct biautomatic structures. For hypoplactic monoids, we construct finite complete rewriting systems and biautomatic structures. For sylvester monoids, which are not finitely presented, we prove that the standard presentation is an infinite complete rewriting system, and construct biautomatic structures. Consequently, the monoid algebras corresponding to monoids of these classes are automaton algebras in the sense of Ufnarovskij.

Robotics technology has been applied to a wide variety of sectors and with a higher economic and social impact. In the last decades it has been one of the main elements of industrial manufacturing automation where about 1.5 million robots are currently operating, which means that 4 to 5 million workers are operating those systems. From 2014 to 2016, robot installations are estimated to increase by 6% on average per year. Besides this, in recent years the number of professional service robots has increased enormously in military and civil applications (around 130 thousand units).

In this work, a multi-objective mixed integer linear programming (moMILP) model is presented for the design and planning of sustainable closed loop supply chains. It includes strategic decisions such as facility location, definition of transportation modes, technology selection and allocation, as well as tactical decisions. The model includes four objectives: 1) The economic pillar, measured through the net present value (NPV); 2) the environmental pillar, which includes Life Cycle Assessment (LCA), through the application of the ReCiPe methodology; 3 and 4) The social pillar measured using two socio-economic indicators applied by the European Union in its Sustainable Development Strategy. The applicability of the model is demonstrated through a representative supply chain case study. Results show that the different objectives influence the supply chain structure and translate in significantly different and conflicting decisions, showing the importance of such type of models to better understand the decisions implications on the different dimensions of sustainability.

Non-steroidal anti-inflammatory drugs exert their pharmacological activity through inhibition of cyclooxygenase 1 and 2 (COX-1 and COX-2). Recent research suggests that a balanced inhibition of both COX-1 and COX-2 is the key to reduce the side-effects exhibited by COX inhibitors. We developed new benzimidazole-based compounds that showed a balanced COX inhibition, supported by molecular docking screening. The human whole blood assays demonstrated that the ester derivatives were potent inhibitors. Competitive saturation transfer difference (STD)-NMR experiments, in the presence of COX-2, using naproxen and diclofenac demonstrated that ester derivatives do not compete with diclofenac for the same binding site, but compete with the allosteric inhibitor naproxen. Combination of NMR spectroscopy with molecular docking has permitted us to detect a new naproxen-like inhibitor, which could be used for future drug development.