Cellulosomes are highly efficient nanomachines that play a fundamental role during the anaerobic deconstruction of complex plant cell wall carbohydrates. The assembly of these complex nanomachines results from the very tight binding of repetitive cohesin modules, located in a noncatalytic molecular scaffold, and dockerin domains located at the C-terminus of the enzyme components of the cellulosome. The number of enzymes found in a cellulosome varies but may reach more than 100 catalytic subunits if cellulosomes are further organized in polycellulosomes, through a second type of cohesin-dockerin interaction. Structural studies have revealed how the cohesin-dockerin interaction mediates cellulosome assembly and cell-surface attachment, while retaining the flexibility required to potentiate catalytic synergy within the complex. Methods that might be applied for the production, purification, and structure determination of cohesin-dockerin complexes are described here. Copyright 2012 Elsevier Inc. All rights reserved.

We can regard Domain-Specific Languages (DSLs) as User Interfaces (UIs) because they bridge the gap
between the domain experts and the computation platforms. Usability of DSLs by domain experts is a key
factor for their successful adoption. The few reports supporting improvement claims are persuasive, but
mostly anecdotal. Systematic literature reviews show that evidences on the effects of the introduction of
DSLs are actually very scarce. In particular, the evaluation of usability is often skipped, relaxed, or at
least omitted from papers reporting the development of DSLs. The few exceptions mostly take place at
the end of the development process, when fixing problems is already too expensive. A systematic
approach, based on techniques for the experimental evaluation of UIs, should be used to assess suitability
of new DSLs. This chapter presents a general experimental evaluation model, tailored for DSLs’
experimental evaluation, and instantiates it in several DSL’s evaluation examples.

Over the last decades, several indices based on ash chemistry and ash fusibility have been used to predict the ash behaviour during coal combustion, namely, its tendency for slagging and fouling. However, due to the physical–chemical differences between coals and biomass, in this work only the applicability of an ash fusibility index (AFI) to the combustion and co-combustion of three types of biomass (straw pellets, olive cake and wood pellets) with coals was evaluated. The AFI values were compared with the behaviour of ash during combustion in a pilot fluidized bed and a close agreement was observed between them. For a better understanding of the mechanisms associated with bed ash sintering, they were evaluated by SEM/EDS and the elements present on the melted ash were identified. Evidences of different sintering mechanisms were found out for the fruit biomass and herbaceous biomass tested, depending on the relative proportions of problematic elements. The particles deposited on a fouling probe inserted in the FBC were analyzed by XRD and the differences between the compounds identified allowed concluding that the studied biomasses present different tendencies for fouling. Identification of KCl and K2SO4 in the deposits confirmed the higher tendency for fouling of fruit biomass tested rather than wood pellets.

Since the 1980’s, several buildings throughout the world have been subject to gas explosions, impact by cars or airplanes, or car bomb attacks. In many cases the effect of the impact or explosion has been the failure of a critical structural member at the perimeter of the building. After the failure, the load supported by that member could not be redistributed and part or all of the structure has collapsed in a progressive manner. The phenomenon that occurs when local failure is not confined to the area of initial distress, and spreads horizontally and/or vertically through the structure, is termed progressive collapse.

Progressive collapse is a relatively rare event, as it requires both an accidental action to cause local damage and a structure that lacks adequate continuity, ductility, and redundancy to prevent the spread of damage. It is technically very difficult and economically prohibitive to design buildings for absolute safety. However it is possible to construct precast concrete buildings that afford an acceptable degree of safety with regard to accidental actions.

A structure is normally designed to respond properly, without damage, under normal load conditions, but local and/or global damages cannot be avoided under the effect of an unexpected, but moderate degree of accidental overload. Properly designed and constructed structures usually possess reasonable probability not to collapse catastrophically under such loads, depending on different factors, for example: the type of loading; the degree and the location of accidental loading in regard to the structure and its structural members; the type of structural system, the construction technology, and the spans between structural vertical members, etc.

No structure can be expected to be totally resistant to actions arising from an unexpected and extreme cause, but it should not be damaged to an extent that is disproportionate to the original cause.

The aim of fib Bulletin 63 is to summarize the present knowledge on the subject and to provide guidance for the design of precast structures against progressive collapse. This is addressed in terms of (a) the classification of the actions, (b) their effect on the structural types, (c) the strategies to cope with such actions, (d) the design methods and (e) some typical detailing, all supplemented with illustrations from around the world, and some model calculations.

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In this paper, the use of non-optimality spheres in a simplicial branch and bound (B&B) algorithm is investigated. In this context, some considerations regarding the use of bisection on the longest edge in relation with ideas of Reiner Horst are reminded. Three arguments highlight the merits of bisection of simplicial subsets in B&B schemes.

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Green and lean paradigms have been adopted by companies in order to manage their relationships with suppliers in a supply chain management context, but nearly always separately and with little understanding of their influence on company performance. This paper proposes a theoretical framework for the analysis of the influence of green and lean upstream supply chain management practices on the sustainable development of businesses. To attend this objective, a set of performance measures covering economic (operational cost, environmental cost, and inventory cost), environmental (business wastage, green image, and CO2 emission), and social (corruption risk, supplier screening and local supplier) perspectives is proposed. An explanatory case study was conducted at a Portuguese automaker to test qualitatively the validity of the proposed theoretical framework. From the case study, a model is suggested, which encompasses the relationships between green and lean upstream supply chain practices and sustainable business development.

A clutch of several crushed eggs and embryos from the Late Jurassic (near the Kimmeridgian-Tithonian
boundary), Lourinhã Formation, Portugal contains a complete maxilla, erupted and scattered teeth,
and presacral vertebrae. The maxilla bears four teeth separated by individualized interdental plates,
the dorsal process of the maxilla is confluent with the maxillary body, the ventral rim of the antorbital
fossa is parallel to the tooth row, and the anterior border of the maxilla forms a right angle with the
ventral margin. The teeth are conical and recurved distally with carinae on mesial and distal sides. The
vertebrae are amphiplatyan, with a ventral pair of neurovascular foramina and heavily pitted articular
facets. These fossils allow unambiguous association of basal theropod osteology (Megalosauroidea) with
a new eggshell morphotype. Synchrotron micro-computed tomographic scanning (SRμCT), scanning
electron microscopy, and thin-sections under polarized and normal light revealed that the outer
ornamentation of the eggshell is composed of anastomosing ridges and islets, the pores communicate
near the outer region of the eggshells, and in radial section they are irregular canals that ramify towards
the surface. Micro-proto induced x-ray emission (micro-PIXE) analysis of the eggshell (excluding pores)
revealed the presence of Mg, Fe, Mn (0.33%, 0.27% and 0.18%, respectively) and several trace elements,
with a corresponding loss of Ca (39.4% detected but 40.0% expected for calcite), which suggests minimal
eggshell diagenesis. The eggshells do not luminesce, which could imply that no diagenetic alteration
took effect. However, the quenching effect of Fe2+ has to be taken into consideration. Conversely,
luminescence is observed in the pores since they are filled with sediment, composed of phyllosilicates,
as revealed by SRμCT, micro-PIXE and x-ray diffraction analyses.

Goal-Oriented Requirements Engineering (GORE) has received increasing attention over the past few years.
There are several goal-oriented approaches, each one using different kinds of models. We argue that it would be useful to relate them or even perform transformations among them automatically, in order to understand their similarities and differences, their advantages and disadvantages, allowing a possible migration or comparison between approaches. This is something that has not received enough attention. In this paper
we propose the definition and implementation of goal model transformations between i* and KAOS. As an immediate contribution, the approach can be used to migrate from one goal model to another through automatic model transformations. This approach also contributes to relate the concepts of i* and KAOS models and will help, for example, a development team in making the decision on which approach to follow, according to the nature of the project and the expressiveness of an approach to represent certain concepts
(e.g., obstacles are represented explicitly in KAOS, but not in i*). Another contribution is to facilitate communication among members of the same team, if they are specialized in different approaches.

Inductive superconducting fault current limiters have already demonstrated their technical viability in electrical networks. Its architecture and robustness make them potentially adequate for distribution networks, and this type of devices is considered as an enabling technology for the advent of embedded generation with renewable energy sources. In order to promote the growth and maturity of these superconducting technologies, fast design tools must be developed, allowing simulating devices with different materials in grids with diverse characteristics. This work presents advances in the development of such tool, which, at present stage, is an effective alternative to software simulations by finite elements methods, reducing dramatically computation time. The algorithms are now compared with experimental results from a laboratory scale prototype, showing the need to refine them.

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The quadrate in nonavian theropods is incredibly diverse morphologically; however this morphological disparity has been underestimated for taxonomic purposes. The quadrate topological homologies and anatomy, as well as the terminology, among nonavian theropod clades are reviewed. In order to evaluate the phylogenetic potential and investigate the evolutionary transformations of the quadrate, we conducted a Catalano-Goloboff phylogenetic morphometric analysis using 3 morphometric characters, a total of 28 landmarks coded for 23 taxa, as well as a cladistic analysis using 115 discrete quadrate-related characters coded for 43 taxa. The cladistic analysis provides a fully resolved tree mirroring the current classification of nonavian theropods. The quadrate morphology by its own provides a wealth of data with strong phylogenetic signal. Several unambiguous synapomorphies support nonavian theropod relationships and the resulting consensus tree allows inference of major trends in the evolution of this bone. Important synapomorphies include: for Abelisauridae, a lateral ramus extending to the ectocondyle; for Tetanurae, the absence of the lateral process; for Spinosauridae, a medial curvature of the ventral part of the pterygoid ramus occurring just above the mandibular articulation; for Neotetanurae, an anterior margin of the pterygoid flange formed by a roughly parabolic margin; and for Tyrannosauroidea, a semi-oval pterygoid flange shape in medial view. The Catalano-Goloboff phylogenetic morphometric analysis reveals two main morphotypes of the mandibular articulation of the quadrate linked to function. The first morphotype, characterized by an anteroposteriorly broad mandibular articulation with two ovoid/subcircular condyles roughly subequal in size, is found in Ceratosauria, Tyrannosauroidea and Oviraptorosauria. This morphotype allows a very weak displacement of the mandible laterally. The second morphotype is characterized by an elongate and anteroposteriorly narrow mandibular articulation and a long and parabolic/sigmoid ectocondyle. Present in Megalosauroidea, Allosauroidea and Dromaeosauridae, this morphotype permits the lower jaw rami to be displaced laterally when the mouth opened.

This paper describes a novel upper-bound formulation of limit analysis. This formulation is an innovative variant of an existing two-field mixed formulation based on the augmented Lagrangian method also developed by the authors. A natural approach is used to describe the deformation of each finite element. Furthermore, and in contrast to the previous formulation, two independent field approximations are now both used to define the velocity field, defined globally and at element level. It is shown that this feature allows a governing system of uncoupled linear equations to be obtained. Some numerical examples in plane strain conditions are presented in order to illustrate the current model performance. In conclusion, the potential and advantages of this new approach are discussed.

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The basal part of the Triassic-Jurassic (Rhaetian-Sinemurian) Kap Stewart Formation, exposed at Jameson Land, East Greenland, yields an extensive coprolite collection from black, parallel-laminated mudstone (“paper shale”), representing an open lacustrine system. Preliminary investigations show three different types of coprolites: elongated cylindrical masses, composed of irregularly wrapped layers; elongated cylindrical masses with constriction marks; and spirally-coiled specimens.

The main objective of this paper is to propose a conceptual model about the influence of lean, agile, resilient, and green ({LARG)} practices on supply chain operational, economic and environmental performance. This model is based on the literature review about the four supply chain management paradigms and also performance measurement systems. This paper contributes to the literature by introducing a new model to improve the leanness, agility, resilience, and greenness of manufacturing supply chains. Among the suggested {LARG} practices, the ones influencing more the supply chain performance are the just in time and also the supplier relationships. Also the supply chain performance measures with more {LARG} practices influencing them are the inventory levels and the time, that is, the supply chain’s operational performance is the most affected by the simultaneous paradigms deployment in the supply chain.

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