Publications

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2019
Pandeirada, Carolina O., Élia Maricato, Sónia S. Ferreira, Viviana G. Correia, Benedita A. Pinheiro, Dmitry V. Evtuguin, Angelina S. Palma, Alexandra Correia, Manuel Vilanova, Manuel A. Coimbra, and Cláudia Nunes. "{Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides.}." Carbohydrate polymers. 222 (2019): 114962. Abstract

The relevance of microalgae biotechnology for producing high-value compounds with biomedical application, such as polysaccharides, has been increasing. Despite this, the knowledge about the composition and structure of microalgae polysaccharides is still scarce. In this work, water-soluble polysaccharides from Nannochloropsis oculata were extracted, fractionated, structurally analysed, and subsequently tested in terms of immunostimulatory activity. A combination of sugar and methylation analysis with interaction data of carbohydrate-binding proteins using carbohydrate microarrays disclosed the complex structural features of the different polysaccharides. These analyses showed that the water-soluble polysaccharides fractions from N. oculata were rich in ($\beta$1→3, $\beta$1→4)-glucans, ($\alpha$1→3)-, ($\alpha$1→4)-mannans, and anionic sulphated heterorhamnans. The immunostimulatory assay highlighted that these fractions could also stimulate murine B-lymphocytes. Thus, the N. oculata water-soluble polysaccharides show potential to be further explored for immune-mediated biomedical applications.

2018
Loureiro, LR, DP Sousa, D. Ferreira, W. Chai, L. Lima, C. Pereira, CB Lopes, VG Correia, LM Silva, C. Li, LL Santos, JA Ferreira, A. Barbas, A. S. Palma, C. Novo, and PA Videira. "Novel Monoclonal Antibody L2A5 Specifically Targeting sialyl-Tn and Short Glycans Terminated by alpha-2-6 Sialic Acids." Sci Rep.. 8.1 (2018): 12196.
2014
Gao, Chao, Yan Liu, Hongtao Zhang, Yibing Zhang, Michiko N. Fukuda, Angelina S. Palma, Radoslaw P. Kozak, Robert A. Childs, Motohiro Nonaka, Zhen Li, Don L. Siegel, Peter Hanfland, Donna M. Peehl, Wengang Chai, Mark I. Greene, and Ten Feizi. "Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array." Journal of Biological Chemistry. 289 (2014): 16462-16477. Abstract
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2013
Crusat, Martin, Junfeng Liu, Angelina S. Palma, Robert A. Childs, Yan Liu, Stephen A. Wharton, Yi Pu Lin, Peter J. Coombs, Stephen R. Martin, Mikhail Matrosovich, Zi Chen, David J. Stevens, Vo Minh Hien, Tran Tan Thanh, Le Nguyen Truc Nhu, Lam Anh Nguyet, Do Quang Ha, Rogier H. van Doorn, Tran Tinh Hien, Harald S. Conradt, Makoto Kiso, Steve J. Gamblin, Wengang Chai, John J. Skehel, Alan J. Hay, Jeremy Farrar, Menno D. de Jong, and Ten Feizi. "Changes in the hemagglutinin of H5N1 viruses during human infection - Influence on receptor binding." Virology. 447 (2013): 326-337. Abstract
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Neu, Ursula, Stacy-Ann A. Allen, Barbel S. Blaum, Yan Liu, Martin Frank, Angelina S. Palma, Luisa J. Stroh, Ten Feizi, Thomas Peters, Walter J. Atwood, and Thilo Stehle. "A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus." PLoS pathogens. 9 (2013): e1003688. Abstract
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Neu, Ursula, Zaigham Mahmood Khan, Benjamin Schuch, Angelina S. Palma, Yan Liu, Michael Pawlita, Ten Feizi, and Thilo Stehle. "Structures of B-Lymphotropic Polyomavirus VP1 in Complex with Oligosaccharide Ligands." PLoS pathogens. 9 (2013): e1003714. Abstract
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2010
Neu, Ursula, Melissa S. Maginnis, Angelina S. Palma, Luisa J. Stroeh, Christian D. S. Nelson, Ten Feizi, Walter J. Atwood, and Thilo Stehle. "Structure-Function Analysis of the Human JC Polyomavirus Establishes the LSTc Pentasaccharide as a Functional Receptor Motif." Cell Host & Microbe. 8 (2010): 309-319. Abstract
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