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This study describes the characterisation of whey protein hydrolysates obtained from tryptic hydrolysis to assess their application as ingredients with angiotensin-converting-enzyme (ACE) inhibitory action. The levels of a-lactalbumin (alpha-la) and P-lactoglobulin (beta-lg) remaining after hydrolysis were quantified. Peptides were separated by RP-HPLC, and Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR), the most potent beta-lg-derived ACE-inhibitory peptide was monitored. A correlation curve was established for the production of this peptide as a function of hydrolysis time. Heat-induced gelation of hydrolysates was studied by small-deformation rheology. The gelation times and the strength of the final gels were highly dependent on the degree of hydrolysis. Smaller peptides liberated by hydrolysis contributed to the inability of whey protein hydrolysates to gel. (c) 2006 Elsevier Ltd. All rights reserved.

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This paper presents the design of a test rig for an all HTS linear synchronous motor. Although this motor showed to have several unattractive characteristics, its design raised a number of problems which must be considered in future HTS machines design. HTS electromagnetic properties led to the development of new paradigms in electrical machines and power systems, as e. g. in some cases iron removal and consequent assembly of lighter devices. This is due to superconductor's ability to carry high currents with minimum losses and consequent generation in the surrounding air of flux densities much higher than the allowed by ferromagnetic saturation. However, severe restrictions in HTS power devices design that goes further beyond cryogenic considerations must be accounted in. This is usually the case when BSCCO tapes are used as conductors. Its bending limitations and the presence of flux components perpendicular to tape surface, due to the absence of iron, have to be considered for it may turn some possible applications not so attractive or even practically unfeasible. An all HTS linear synchronous motor built by BSCCO tapes as armature conductors and two trapped-flux YBCO bulks in the mover was constructed and thrust force measurements are starting to be performed. Although the device presents severe restrictions due to the exposed and other reasons, it allowed systematising its design. A pulsed-field magnetiser to generate opposite fluxes for both YBCO bulks is also detailed. Thrust force numerical predictions were already derived and presented.

This paper presents the design of a test rig for an all HTS linear synchronous motor. Although this motor showed to have several unattractive characteristics, its design raised a number of problems which must be considered in future HTS machines design. HTS electromagnetic properties led to the development of new paradigms in electrical machines and power systems, as e. g. in some cases iron removal and consequent assembly of lighter devices. This is due to superconductor's ability to carry high currents with minimum losses and consequent generation in the surrounding air of flux densities much higher than the allowed by ferromagnetic saturation. However, severe restrictions in HTS power devices design that goes further beyond cryogenic considerations must be accounted in. This is usually the case when BSCCO tapes are used as conductors. Its bending limitations and the presence of flux components perpendicular to tape surface, due to the absence of iron, have to be considered for it may turn some possible applications not so attractive or even practically unfeasible. An all HTS linear synchronous motor built by BSCCO tapes as armature conductors and two trapped-flux YBCO bulks in the mover was constructed and thrust force measurements are starting to be performed. Although the device presents severe restrictions due to the exposed and other reasons, it allowed systematising its design. A pulsed-field magnetiser to generate opposite fluxes for both YBCO bulks is also detailed. Thrust force numerical predictions were already derived and presented.

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The possibility of preparation of ophthalmic drug delivery systems using compressed anti-solvent technology was evaluated. Eudragit RS 100 and RL 100 were used as drug carriers, acetazolamide was the model drug processed. Compressed anti-solvent experiments were carried out as a semi-continuous or a batch operation from a liquid solution of polymer(s) + solute dissolved in acetone. Both techniques allowed the recovery of composite particles, but the semi-continuous operation yielded smaller and less aggregated populations than the batch operation. The release behaviour of acetazolamide from the prepared microparticles was studied and most products exhibited a slower release than the single drug. Moreover, the release could be controlled to some extent by varying the ratio of the two Eudragit used in the formulation and by selecting one or the other anti-solvent technique. Simple diffusion models satisfactorily described the release profiles. Composites specifically produced by semi-continuous technique have a drug release rate controlled by a diffusion mechanism, whereas for composites produced by the batch operation, the polymer swelling also contributes to the overall transport mechanism. © 2006 Elsevier B.V. All rights reserved.

The possibility of preparation of ophthalmic drug delivery systems using compressed anti-solvent technology was evaluated. Eudragit RS 100 and RL 100 were used as drug carriers, acetazolamide was the model drug processed. Compressed anti-solvent experiments were carried out as a semi-continuous or a batch operation from a liquid solution of polymer(s) + solute dissolved in acetone. Both techniques allowed the recovery of composite particles, but the semi-continuous operation yielded smaller and less aggregated populations than the batch operation. The release behaviour of acetazolamide from the prepared microparticles was studied and most products exhibited a slower release than the single drug. Moreover, the release could be controlled to some extent by varying the ratio of the two Eudragit used in the formulation and by selecting one or the other anti-solvent technique. Simple diffusion models satisfactorily described the release profiles. Composites specifically produced by semi-continuous technique have a drug release rate controlled by a diffusion mechanism, whereas for composites produced by the batch operation, the polymer swelling also contributes to the overall transport mechanism. © 2006 Elsevier B.V. All rights reserved.

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Cobalt compounds of the general formula [COX2(alpha-diimine)], where X = Cl or I and the alpha-diimines are 1,4-diaryl-2,3-dimethyl-1,4-diaza-1,3-butadiene (Ar-DAB) and bis(aryl)acenaphthenequinonediimine (Ar-BIAN) were synthesized by the direct reaction of the anhydrous cobalt salts CoCl2 or CoI2 and the corresponding alpha-diinline ligand in dried CH2Cl2. The synthesized compounds are [Co(Ph-DAB)Cl-2] (1a), [Co(o,o',p-Me3C6H2-DAB)Cl-2] (1b), and [Co(o,o'iPr(2)C(6)H(3)-DAB)Cl-2] (1c) with the ligands Ar-DAB, and also [Co(o,o',p-Me3C6H2-BIAN)I-2] (2'b) with the ligand Ar-BIAN. The crystal structures of all the compounds were solved by single-crystal X-ray diffraction. In all cases the cobalt atom is in a distorted tetrahedron, which is built up of two halide atoms and two nitrogen atoms of the alpha-dimune ligand. X-band EPR measurements of polycrystalline samples performed on compounds 1b, 1c, and 2'b indicate a high-spin Col, ion (S = 3/2) in an axially distorted environment. Single-crystal EPR experiments on compounds 1b and 1c allowed us to evaluate the orientation of the g tensor in the molecular frame. (c) Wiley-VCH Verlag GmbH & Co.

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