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Wain, Alison, Diogo Castro, {Maria Fernanda} Rollo, Frederico Nogueira, Gon{\c c}alo Santos, {Maria Gra{\c da c}a} Filipe, Isabel Tissot, {Jorge Miguel} Sampaio, {José Paulo} Santos, Manuel Lemos, Marta Manso, Matthias Tissot, Mauro Guerra, Miles Oglethorpe, Pedro Amaro, Pedro Pedroso, Rui Silva, Sofia Pessanha, and {Tiago A. N. } Silva. Cultura Material, Cultura Científica: Património Industrial para o Futuro. Portugal: Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2021. Abstract

Material, Culture, Scientific Culture: Industrial Heritage for the Future

Santos, J. P., and M. F. Laranjeira. Métodos Matemáticos para Físicos e Engenheiros., 2004. Abstract
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Conference Paper
Pohl, Randolf, François Nez, Luis M. P. Fernandes, Marwan Abdou Ahmed, Fernando D. Amaro, Pedro Amaro, François Biraben, João M. R. Cardoso, Daniel S. Covita, Andreas Dax, Satish Dhawan, Marc Diepold, Beatrice Franke, Sandrine Galtier, Adolf Giesen, Andrea L. Gouvea, Johannes Götzfried, Thomas Graf, Theodor W. Hänsch, Malte Hildebrandt, Paul Indelicato, Lucile Julien, Klaus Kirch, Andreas Knecht, Paul Knowles, Franz Kottmann, Julian J. Krauth, Eric-Olivier Le Bigot, Yi-Wei Liu, José A. M. Lopes, Livia Ludhova, Jorge Machado, Cristina M. B. Monteiro, Françoise Mulhauser, Tobias Nebel, Paul Rabinowitz, Joaquim M. F. dos Santos, Jose Paulo Santos, Lukas A. Schaller, Karsten Schuhmann, Catherine Schwob, Csilla I. Szabo, David Taqqu, João F. C. A. Veloso, Andreas Voss, Birgit Weichelt, and Aldo Antognini. "Laser Spectroscopy of Muonic Atoms and Ions." In Proceedings of the 12th International Conference on Low Energy Antiproton Physics (LEAP2016), 1-12. Journal of the Physical Society of Japan, 2017. Abstract
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Lopes, G., D. Tendeiro, J. P. Santos, and P. Vieira. "Monte Carlo Simulation of Radiation through the Human Retina Using Geant4.", 431-434. Vol. 41. Cham: Springer International Publishing, 2014. Abstract
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Lopes, G., D. Tendeiro, J. P. Santos, and P. Vieira. "Monte Carlo Simulation of Radiation through the Human Retina Using Geant4.", 431-434. Vol. 41. Cham: Springer International Publishing, 2014. Abstract
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Lopes, A., A. Gabriel, J. Machado, P. Ribeiro, R. Gomes, Jo M. P. o Coelho, C. O. Silva, C. P. Reis, J. P. Santos, and P. Vieira. "Multiple Source Phototherapy in Breast Cancer: A Viability Study." In 9th International Conference on Biomedical Electronics and Devices, 247-250. SCITEPRESS - Science and and Technology Publications, 2016. Abstract
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Journal Article
Amaro, Pedro, Sophie Schlesser, Mauro Guerra, Eric-Olivier Le Bigot, Jean-Michel Isac, Pascal Travers, Jose Paulo Santos, Csilla Szabo, Alexandre Gumberidze, and Paul Indelicato. "Absolute Measurement of the Relativistic Magnetic Dipole Transition Energy in Heliumlike Argon." Phys. Rev. Lett. 109 (2012): 043005. AbstractWebsite

The 1s2s 3S1 ! 1s2 1S0 relativistic magnetic dipole transition in heliumlike argon, emitted by the plasma of an electron-cyclotron resonance ion source, has been measured using a double-flat crystal x-ray spectrometer. Such a spectrometer, used for the first time on a highly charged ion transition, provides absolute (reference-free) measurements in the x-ray domain. We find a transition energy of 3104.1605(77) eV (2.5 ppm accuracy). This value is the most accurate, reference-free measurement done for such a transition and is in good agreement with recent QED predictions.

Amaro, Pedro, Sophie Schlesser, Mauro Guerra, Eric-Olivier Le Bigot, Jean-Michel Isac, Pascal Travers, Jose Paulo Santos, Csilla Szabo, Alexandre Gumberidze, and Paul Indelicato. "Absolute Measurement of the Relativistic Magnetic Dipole Transition Energy in Heliumlike Argon." Physical Review Letters 109 (2012): 043005. AbstractWebsite

The 1s2s 3S1 - 1s2 1S0 relativistic magnetic dipole transition in heliumlike argon, emitted by the plasma of an electron-cyclotron resonance ion source, has been measured using a double-flat crystal x-ray spectrometer. Such a spectrometer, used for the first time on a highly charged ion transition, provides absolute (reference-free) measurements in the x-ray domain. We find a transition energy of 3104.1605(77) eV (2.5 ppm accuracy). This value is the most accurate, reference-free measurement done for such a transition and is in good agreement with recent QED predictions.

Amaro, P., S. Schlesser, M. Guerra, E. Le Bigot, J. P. Santos, C. I. Szabo, A. Gumberidze, and P. Indelicato. "Absolute measurements and simulations of x-ray line energies of highly charged ions with a double-crystal spectrometer." T156 (2013): 014104. AbstractWebsite
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Amaro, P., S. Schlesser, M. Guerra, E. Le Bigot, J. P. Santos, C. I. Szabo, A. Gumberidze, and P. Indelicato. "Absolute measurements and simulations of x-ray line energies of highly charged ions with a double-crystal spectrometer." Physica Scripta T156 (2013): 014104. AbstractWebsite
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Machado, Jorge, {Patrícia M. S. } Carvalho, Ana Félix, Delfin Doutel, {José Paulo} Santos, {Maria Luísa} Carvalho, and Sofia Pessanha. "Accuracy improvement in XRF analysis for the quantification of elements ranging from tenths to thousands μg g-1in human tissues using different matrix reference materials." Journal of Analytical Atomic Spectrometry 35 (2020): 2920-2927. Abstract

In this work, we aim at achieving the most accurate quantitative determination of elements in human tissues by means of X-ray Fluorescence spectrometry using the external calibration approach. A calibration curve built using a set of certified reference materials (CRM) of animal tissue was compared with the one obtained with a set of CRMs of plants and leaves with lower atomic number Z but with correction of the matrix using the scattering peaks of the X-ray tube anode. Finally, a calibration curve combining the two sets of CRMs was built and the accuracy of the quantification using the three methods was compared and a more precise method of quantification was obtained. This improved approach was tested on five paired samples of normal and tumour human tissue. Despite the high heterogeneity of the samples, and given the improvement in accuracy of the measurements, significant differences were found in the elemental concentration of low-Z elements. This journal is

Ensina, Ana, Patr{\'ı}cia M. Carvalho, Jorge Machado, Maria Lu{\'ı}sa Carvalho, Diogo Casal, Diogo Pais, José Paulo Santos, António A. Dias, and Sofia Pessanha. "Analysis of human tissues using Energy Dispersive X Ray Fluorescence – Dark matrix determination for the application to cancer research." Journal of Trace Elements in Medicine and Biology 68 (2021): 126837. AbstractWebsite
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Guerra, M., P. Amaro, C. I. Szabo, A. Gumberidze, P. Indelicato, and J. P. Santos. "Analysis of the charge state distribution in an ECRIS Ar plasma using high-resolution x-ray spectra." Journal of Physics B: Atomic, Molecular and Optical Physics 46 (2013): 065701. AbstractWebsite

In this work, we obtained a charge state distribution inside an Ar plasma produced by an electron–cyclotron-resonance ion source. The processes that lead to the observed lines in x-ray spectra are identified and included in the simulated x-ray spectrum. The geometrical constraints of the flat double crystal spectrometer, used to measure the x-ray spectrum, are investigated as they are crucial for correctly obtaining the ion densities from the observed transition amplitudes. Multiple electron impact ionization is included, and a realistic electron velocity distribution is taken into account. The charge state distribution of the Ar ions is compared to measured extracted ionic currents.

Guerra, M., P. Amaro, C. I. Szabo, A. Gumberidze, P. Indelicato, and J. P. Santos. "Analysis of the charge state distribution in an ECRIS Ar plasma using high-resolution x-ray spectra." Journal of Physics B: Atomic, Molecular and Optical Physics 46 (2013): 065701. AbstractWebsite

In this work, we obtained a charge state distribution inside an Ar plasma produced by an electron–cyclotron-resonance ion source. The processes that lead to the observed lines in x-ray spectra are identified and included in the simulated x-ray spectrum. The geometrical constraints of the flat double crystal spectrometer, used to measure the x-ray spectrum, are investigated as they are crucial for correctly obtaining the ion densities from the observed transition amplitudes. Multiple electron impact ionization is included, and a realistic electron velocity distribution is taken into account. The charge state distribution of the Ar ions is compared to measured extracted ionic currents.

Safari, L., J. P. Santos, P. Amaro, K. Jankala, and F. Fratini. "Analytical evaluation of atomic form factors: Application to Rayleigh scattering." Journal of Mathematical Physics 56 (2015): 052105-9. AbstractWebsite
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Guimarães, D., J. P. Santos, M. L. Carvalho, M. S. Diniz, B. House, and V. M. Miller. "Analytical evidence of heterogeneous lead accumulation in the hypothalamic defence area and nucleus tractus solitarius." NeuroToxicology 44 (2014): 91-97. AbstractWebsite

Lead is a potent toxicant associated with adverse cardiovascular effects and hypertension in children. Yet, few studies have determined if autonomic dysfunction associated with lead exposure involves brain regions which regulate autonomic responses. Central autonomic nuclei such as the nucleus tractus solitarius (NTS) and hypothalamic defence area (HDA) may be particularly sensitive to lead infiltration because they are adjacent to ventricles and areas with semi-permeable blood-brain-barriers. To understand if autonomic nuclei are sensitive to lead accumulation Wistar rats were exposed to lead from the gestational period and lead levels were quantified in brain regions that regulate arterial pressure: the NTS and the HDA. Energy dispersive X-ray fluorescence (EDXRF) was used to quantify total brain lead levels and revealed no differences between exposed and control tissues; measured values were close to the detection limit (2μg/g). Electrothermal atomic absorption spectrometry (ETAAS) was also used, which has a greater sensitivity, to quantify lead. There was ∼2.1μg/g lead in the NTS and ∼3.1μg/g lead in the HDA of exposed rats, and no lead in the control rats. There were greater lead levels in the HDA (∼50%) as compared with the NTS. Pathology studies revealed more prominent lead granules in the HDA as compared with the NTS. Increased microglia and astrocyte activation was also noted in the NTS of lead exposed rats as compared with the HDA. Regional differences in neuro-inflammatory responses likely contribute to heterogeneous lead accumulation, with enhanced clearance of lead in the NTS. Future studies will resolve the mechanisms underpinning tissue-specific lead accumulation.

Guimarães, D., J. P. Santos, M. L. Carvalho, M. S. Diniz, B. House, and V. M. Miller. "Analytical evidence of heterogeneous lead accumulation in the hypothalamic defence area and nucleus tractus solitarius." NeuroToxicology 44 (2014): 91-97. AbstractWebsite

Lead is a potent toxicant associated with adverse cardiovascular effects and hypertension in children. Yet, few studies have determined if autonomic dysfunction associated with lead exposure involves brain regions which regulate autonomic responses. Central autonomic nuclei such as the nucleus tractus solitarius (NTS) and hypothalamic defence area (HDA) may be particularly sensitive to lead infiltration because they are adjacent to ventricles and areas with semi-permeable blood-brain-barriers. To understand if autonomic nuclei are sensitive to lead accumulation Wistar rats were exposed to lead from the gestational period and lead levels were quantified in brain regions that regulate arterial pressure: the NTS and the HDA. Energy dispersive X-ray fluorescence (EDXRF) was used to quantify total brain lead levels and revealed no differences between exposed and control tissues; measured values were close to the detection limit (2μg/g). Electrothermal atomic absorption spectrometry (ETAAS) was also used, which has a greater sensitivity, to quantify lead. There was ∼2.1μg/g lead in the NTS and ∼3.1μg/g lead in the HDA of exposed rats, and no lead in the control rats. There were greater lead levels in the HDA (∼50%) as compared with the NTS. Pathology studies revealed more prominent lead granules in the HDA as compared with the NTS. Increased microglia and astrocyte activation was also noted in the NTS of lead exposed rats as compared with the HDA. Regional differences in neuro-inflammatory responses likely contribute to heterogeneous lead accumulation, with enhanced clearance of lead in the NTS. Future studies will resolve the mechanisms underpinning tissue-specific lead accumulation.

Safari, L., P. Amaro, J. P. Santos, and F. Fratini. "Angular and polarization analysis for two-photon decay of <span class="aps-inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML"><mrow><mn>2</mn><mi>s</mi></mrow></math>&." Physical Review A 90 (2014): 014502. AbstractWebsite

The amplitude of two-photon transitions between hyperfine states in hydrogenlike ions is derived based on the relativistic Dirac equation and second-order perturbation theory. We study angular and linear polarization properties of the photon pair emitted in the decay of $2s$ states, where spin-flip and non-spin-flip transitions are highlighted. We pay particular attention to hydrogenlike uranium, since it is an ideal candidate for investigating relativistic and high-multipole effects, such as spin-flip transitions. Two types of emission patterns are identified: (i) non-spin-flip transitions are found to be characterized by an angular distribution of the type $W($\theta${})$\sim${}1+{cos}^{2}$\theta${}$ while the polarizations of the emitted photons are parallel; and (ii) spin-flip transitions have somewhat smaller decay rates and are found to be characterized by an angular distribution of the type $W($\theta${})$\sim${}1$-${}1/3{cos}^{2}$\theta${}$ while the polarizations of the emitted photons are orthogonal, where $$\theta${}$ is the angle between photons directions. Deviations due to nondipole and relativistic contributions are evaluated for both types of transitions. This work is the first step toward exploring the effect of the nucleus over the angular and polarization properties of the photon pairs emitted by two-photon transitions.

Safari, L., P. Amaro, J. P. Santos, and F. Fratini. "Angular and polarization analysis for two-photon decay of <span class="aps-inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML"><mrow><mn>2</mn><mi>s</mi></mrow></math>&." Physical Review A 90 (2014): 014502. AbstractWebsite

The amplitude of two-photon transitions between hyperfine states in hydrogenlike ions is derived based on the relativistic Dirac equation and second-order perturbation theory. We study angular and linear polarization properties of the photon pair emitted in the decay of $2s$ states, where spin-flip and non-spin-flip transitions are highlighted. We pay particular attention to hydrogenlike uranium, since it is an ideal candidate for investigating relativistic and high-multipole effects, such as spin-flip transitions. Two types of emission patterns are identified: (i) non-spin-flip transitions are found to be characterized by an angular distribution of the type $W($\theta${})$\sim${}1+{cos}^{2}$\theta${}$ while the polarizations of the emitted photons are parallel; and (ii) spin-flip transitions have somewhat smaller decay rates and are found to be characterized by an angular distribution of the type $W($\theta${})$\sim${}1$-${}1/3{cos}^{2}$\theta${}$ while the polarizations of the emitted photons are orthogonal, where $$\theta${}$ is the angle between photons directions. Deviations due to nondipole and relativistic contributions are evaluated for both types of transitions. This work is the first step toward exploring the effect of the nucleus over the angular and polarization properties of the photon pairs emitted by two-photon transitions.

Surzhykov, A., A. Volotka, F. Fratini, J. P. Santos, P. Indelicato, G. Plunien, Th Stöhlker, and S. Fritzsche. "Angular correlations in the two-photon decay of heliumlike heavy ions." Physical Review A 81 (2010): 042510. AbstractWebsite
The two-photon decay of heavy, helium-like ions is investigated based on second-order perturbation theory and Dirac’s relativistic equation. Special attention has been paid to the angular emission of the two photons (i.e., how the angular correlation function depends on the shell structure of the ions in their initial and final states). Moreover, the effects from the (electric and magnetic) nondipole terms in the expansion of the electron-photon interaction are discussed. Detailed calculations have been carried out for the two-photon decay of the 1s2s1S0, 1s2s3S1, and 1s2p3P0 states of helium-like Xe52+, Au77+, and U90+ ions.
Surzhykov, A., A. Volotka, F. Fratini, J. P. Santos, P. Indelicato, G. Plunien, Th Stöhlker, and S. Fritzsche. "Angular correlations in the two-photon decay of heliumlike heavy ions." Physical Review A 81 (2010): 042510. AbstractWebsite

The two-photon decay of heavy, helium-like ions is investigated based on second-order perturbation theory and Dirac’s relativistic equation. Special attention has been paid to the angular emission of the two photons (i.e., how the angular correlation function depends on the shell structure of the ions in their initial and final states). Moreover, the effects from the (electric and magnetic) nondipole terms in the expansion of the electron-photon interaction are discussed. Detailed calculations have been carried out for the two-photon decay of the 1s2s1S0, 1s2s3S1, and 1s2p3P0 states of helium-like Xe52+, Au77+, and U90+ ions.

Santos, J. P., F. Parente, and P. Indelicato. "Application of B-splines finite basis sets to relativistic two-photon decay rates of 2s level in hydrogenic ions." The European Physical Journal D 3 (1998): 43-52. AbstractWebsite

A theoretical study of the one- and two-photon spontaneous emission rates from the 2 s1/2 state of one-electron ions is presented. High-precision values of the relativistic emission rates for ions with nuclear charge Z up to 100 are obtained through the use of finite basis sets for the Dirac equation constructed from B-splines. Furthermore, we analyze the influence of the inclusion of quantum electrodynamics corrections in the initial and final state energies.

Santos, J. P., Iulian Otel, Joao Silveira, Valentina Vassilenko, António Mata, Maria Luísa Carvalho, José Paulo Santos, and Sofia Pessanha. "Application of Unsupervised Multivariate Analysis Methods to Raman Spectroscopic Assessment of Human Dental Enamel." Computers (2021). AbstractWebsite
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Katriel, Jacob, J. P. Marques, P. Indelicato, A. M. Costa, M. C. Martins, J. P. Santos, and F. Parente. "Approach towards the critical charge of some excited states of the Be isoelectronic series." Physical Review A 90 (2014): 052519-5. AbstractWebsite
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Sampaio, J. M., T. I. Madeira, J. P. Marques, F. Parente, A. M. Costa, P. Indelicato, J. P. Santos, M. - C. Lépy, and Y. Ménesguen. "Approaches for theoretical and experimental determinations of K-shell decay rates and fluorescence yields in Ge." Physical Review A 89 (2014): 012512. AbstractWebsite
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