Biocompatible Polyurea Dendrimers with pH-Dependent Fluorescence

Restani RB, Morgado PI, Ribeiro MP, Correia IJ, Aguiar-Ricardo A, Bonifácio VDB. "Biocompatible Polyurea Dendrimers with pH-Dependent Fluorescence." Angewandte Chemie International Edition. 2012;51:5162-5165.


Biocompatible and biodegradable water-soluble dendrimers comprising ureas within the interior and amino groups on the periphery were synthesized in supercritical carbon dioxide (dendrimer of generation 1 shown in picture). This novel class of dendrimers shows a pH-dependent intrinsic blue fluorescence at very low concentrations, which makes them potential polymeric fluorescent cell markers.



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