Publications

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2018
Vitor Rosa, Ana Gaspari, Filipe Folgosa, Cristina M. Cordas, Pedro Tavares, Teresa Santos-Silva, Sonia Barroso, and Teresa Aviles. "Imine Ligands Based on Ferrocene: Synthesis{,} Structural and Mossbauer Characterization and Evaluation as Chromogenic and Electrochemical Sensors for Hg+2." New J. Chem. (2018): -. AbstractWebsite

The compounds 1-naphthyliminoferrocene{,} 1{,} and 2-methyl-1-naphthyliminoferrocene{,} 2{,} were prepared by the reaction of ferrocenecarboxaldehyde and the corresponding amine{,} 1-naphthylamine and 2-methyl-1-naphthylamine with one drop of pyrrolidine as catalyst{,} in CH2Cl2{,} under inert atmosphere. The compounds were fully characterized by elemental analyses{,} matrix-assisted laser desorption/ionization - time-of-flight mass spectrometry (MALDI-TOF){,} FT-IR{,} 1H and 13C NMR as well as two-dimensional{,} NOESY{,} COSY and HSQC{,} NMR spectroscopy. Mossbauer spectroscopic studies were performed to characterize the iron species in both compounds. The solid-state molecular structures of compounds 1 and 2 were determined by single crystal X-ray diffraction. Analysis of the electrochemical behaviour of complexes 1 and 2 was performed by cyclic and square wave voltammetry. Compounds 1 and 2 were tested as chromogenic and electrochemical sensors for Hg2+.

2017
Watson, C., D. Niks, R. Hille, M. Vieira, B. Schoepp-Cothenet, AT Marques, MJ Romão, T. Santos-Silva, and J. M. Santini. "Electron transfer through arsenite oxidase: Insights into Rieske interaction with cytochrome c." Biochimica et Biophysica Acta - Bioenergetics. 1858 (2017): 865-872. Abstract
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Otrelo-Cardoso, A. R., R. R. Nair, MAS Correia, R. S. C. Cordeiro, A. Panjkovich, D. I. Svergun, T. Santos-Silva, and M. G. Rivas. "Highly selective tungstate transporter protein TupA from Desulfovibrio alaskensis G20." Scientific Reports. 7 (2017). Abstract
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Santos-Silva, Teresa, Pessoa JC, Correia I, Chorna I, Cavaco I, Roy S, Kuznetsov ML, Ribeiro N, Justino G, Marques F, Silva TS, Santos M, Santos HM, Capelo JL, and Doutch J. "Interaction of VIVO(acac)2 with human serum transferrin and albumin." (2017). AbstractWebsite
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Romão, MJ, C. Coelho, T. Santos-Silva, A. Foti, M. Terao, E. Garattini, and S. Leimkühler. "Structural basis for the role of mammalian aldehyde oxidases in the metabolism of drugs and xenobiotics." Current Opinion in Chemical Biology. 37 (2017): 39-47. Abstract
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2016
Correia, MAS, A. R. Otrelo-Cardoso, V. Schwuchow, K. G. V. Sigfridsson Clauss, M. Haumann, MJ Romão, S. Leimkühler, and T. Santos-Silva. "The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes." ACS Chemical Biology. 11 (2016): 2923-2935. Abstract
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Santos-Silva, Teresa, Correia MA, Otrelo-Cardoso AR, Schwuchow V, Sigfridsson Clauss KG, Haumann M, Romão MJ, Leimkühler S, and Santos-Silva T. "The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes." (2016). Abstract
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Martins, Marta, Pedro V. Baptista, Ana Soraia Mendo, Claudia Correia, Paula Videira, Antonio S. Rodrigues, J. Muthukumaran, Teresa Santos-Silva, Ana Silva, Fatima M. C. Guedes da Silva, Joana Gigante, Antonio Duarte, Malgorzata Gajewska, and Alexandra R. Fernandes. "In vitro and in vivo biological characterization of the anti-proliferative potential of a cyclic trinuclear organotin(IV) complex." Molecular Biosystems. 12 (2016): 1015-1023. Abstract
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Santos-Silva, Teresa, Foti A, Hartmann T, Coelho C, Santos-Silva T, Romao MJ, and Leimkuhler S. "Optimization of the expression of Human Aldehyde Oxidase for Investigations of Single Nucleotide Polymorphisms." (2016). Abstract
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Foti, Alessandro, Tobias Hartmann, Catarina Coelho, Teresa Santos-Silva, Maria Joao Romao, and Silke Leimkuehler. "Optimization of the Expression of Human Aldehyde Oxidase for Investigations of Single-Nucleotide Polymorphisms." Drug Metabolism and Disposition. 44 (2016): 1277-1285. Abstract
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Santos-Silva, Teresa, Terao M, Romão MJ, Leimkühler S, Bolis M, Fratelli M, Coelho C, Santos-Silva T, and Garattini E. "Structure and function of mammalian aldehyde oxidases." (2016). AbstractWebsite
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2015
Correia, H. D., J. Marangon, CD Brondino, JJG Moura, MJ Romão, P. J. González, and T. Santos-Silva. "Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: Reactivity and molecular details of the enzyme-substrate and enzyme-product interaction." Journal of Biological Inorganic Chemistry. 20 (2015): 219-229. Abstract
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Correia, Hugo D., Jacopo Marangon, Carlos D. Brondino, Jose J. G. Moura, Maria J. Romao, Pablo J. Gonzalez, and Teresa Santos-Silva. "Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas: reactivity and molecular details of the enzyme-substrate and enzyme-product interaction (vol 20, pg 219, 2015)." Journal of Biological Inorganic Chemistry. 20 (2015): 231. Abstract
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Seixas, Joao D., Marino F. A. Santos, Abhik Mukhopadhyay, Ana C. Coelho, Patricia M. Reis, Luis F. Veiros, Ana R. Marques, Nuno Penacho, Ana M. L. Goncalves, Maria J. Romao, Goncalo J. L. Bernardes, Teresa Santos-Silva, and Carlos C. Romao. "A contribution to the rational design of Ru(CO)(3)Cl2L complexes for in vivo delivery of CO." Dalton Transactions. 44 (2015): 5058-5075. Abstract
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Freire, D. M., M. G. Rivas, A. M. Dias, A. T. Lopes, C. Costa, T. Santos-Silva, S. Van Doorslaer, and P. J. González. "The homopentameric chlorite dismutase from Magnetospirillum sp." Journal of Inorganic Biochemistry. 151 (2015): 1-9. Abstract
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De Schutter, Amy, Hugo D. Correia, Diana M. Freire, Maria G. Rivas, Alberto Rizzi, Teresa Santos-Silva, Pablo J. Gonzalez, and Sabine Van Doorslaer. "Ligand Binding to Chlorite Dismutase from Magnetospirillum sp." Journal of Physical Chemistry B. 119 (2015): 13859-13869. Abstract
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Coelho, Catarina, Alessandro Foti, Tobias Hartmann, Teresa Santos-Silva, Silke Leimkuehler, and Maria Joao Romao. "Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase." Nature Chemical Biology. 11 (2015): 779-+. Abstract
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Coelho, C., A. Foti, T. Hartmann, T. Santos-Silva, S. Leimkühler, and MJ Romão. "Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase." Nature Chemical Biology. 11 (2015): 779-783. Abstract
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Pessoa, Joao Costa, Eugenio Garribba, Marino F. A. Santos, and Teresa Santos-Silva. "Vanadium and proteins: Uptake, transport, structure, activity and function." Coordination Chemistry Reviews. 301 (2015): 49-86. Abstract
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2014
Otrelo-Cardoso, Ana Rita, Viola Schwuchow, David Rodrigues, Eurico J. Cabrita, Silke Leimkuehler, Maria Joao Romao, and Teresa Santos-Silva. "Biochemical, Stabilization and Crystallization Studies on a Molecular Chaperone (PaoD) Involved in the Maturation of Molybdoenzymes." Plos One. 9 (2014). Abstract
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Pessoa, Joao Costa, Gisela Goncalves, Somnath Roy, Isabel Correia, Sameena Mehtab, Marino F. A. Santos, and Teresa Santos-Silva. "New insights on vanadium binding to human serum transferrin." Inorganica Chimica Acta. 420 (2014): 60-68. Abstract
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Otrelo-Cardoso, Ana Rita, Marcia Alexandra da Silva Correia, Viola Schwuchow, Dmitri I. Svergun, Maria Joao Romao, Silke Leimkuehler, and Teresa Santos-Silva. "Structural Data on the Periplasmic Aldehyde Oxidoreductase PaoABC from Escherichia coli: SAXS and Preliminary X-ray Crystallography Analysis." International Journal of Molecular Sciences. 15 (2014): 2223-2236. Abstract
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Otrelo-Cardoso, Ana Rita, Rashmi R. Nair, Marcia A. S. Correia, Maria G. Rivas, and Teresa Santos-Silva. "TupA: A Tungstate Binding Protein in the Periplasm of Desulfovibrio alaskensis G20." International Journal of Molecular Sciences. 15 (2014): 11783-11798. Abstract
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Santos, Marino F. A., Isabel Correia, Ana R. Oliveira, Eugenio Garribba, Joao Costa Pessoa, and Teresa Santos-Silva. "Vanadium Complexes as Prospective Therapeutics: Structural Characterization of a V-IV Lysozyme Adduct." European Journal of Inorganic Chemistry (2014): 3293-3297. Abstract
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2013
Seixas, J. D., A. Mukhopadhyay, T. Santos-Silva, L. E. Otterbein, D. J. Gallo, S. S. Rodrigues, B. H. Guerreiro, A. M. L. Gon?alves, N. Penacho, A. R. Marques, A. C. Coelho, P. M. Reis, MJ Romão, and C. C. Romão. "Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics." Dalton Transactions. 42 (2013): 5985-5998. Abstract
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