{Supercritical antisolvent precipitation of PHBV microparticles}

Citation:
Costa MS, Duarte AR, Cardoso MM, Duarte CM. {Supercritical antisolvent precipitation of PHBV microparticles}. International Journal of Pharmaceutics. 2007;328:72-7. copy at https://docentes.fct.unl.pt/ard08968/publications/supercritical-antisolvent-precipitation-phbv-microparticles

Abstract:

The micronization of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from organic solutions using supercritical antisolvent (SAS) technique has been successfully achieved. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 3 to 9 $μ$m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a dichloromethane (DCM) solution. The best process conditions for this mixture were, according to our study, 40 °C, 100 bar, 1 mL min-1 liquid flow and 10 L min-1 carbon dioxide flow. Experiments with polymers containing different HV percentages were carried out. The powders obtained became more spherical as the HV content decreased. © 2006 Elsevier B.V. All rights reserved.

Notes:

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