@article {Duarte2006b,
	title = {{Preparation of ethyl cellulose/methyl cellulose blends by supercritical antisolvent precipitation}},
	journal = {International Journal of Pharmaceutics},
	volume = {311},
	number = {1-2},
	year = {2006},
	note = {n/a},
	pages = {50{\textendash}54},
	abstract = {<p>The supercritical antisolvent (SAS) technique was used to prepare ethyl cellulose/methyl cellulose blends, two biocompatible polymers commonly used as drug carriers in controlled delivery systems. Ethyl cellulose is widely used as a drug carrier. The drug release of the delivery devices can be controlled to some extent by addition of a water-soluble or water swellable polymer, such as methyl cellulose. This leads to the solubility enhancement of poorly water-soluble molecules. SAS experiments were carried out at different operational conditions and microspheres with mean diameters ranging from 5 to 30 $μ$m were obtained. The effect of CO2 and liquid flow, temperature and pressure on particle size and particle size distribution was evaluated. The microspheres were precipitated from a mixture of dichloromethane (DCM) and dimethylsulfoxide (DMSO) (4:1 ratio). The best process conditions for this mixture were according to our study 40{\textdegree}C and 80 bar. {\textcopyright} 2006 Elsevier B.V. All rights reserved.</p>
},
	keywords = {Biocompatible polymers, Micronization, Release systems, Supercritical fluid antisolvent (SAS)},
	issn = {03785173},
	doi = {10.1016/j.ijpharm.2005.12.010},
	author = {Duarte, Ana Rita C and Gordillo, M. D. and Cardoso, M. Margarida and Simpl{\'\i}cio, Ana Lu{\'\i}sa and Duarte, Catarina M.M.}
}
