Financed Projects

CO-Releasing Molecules 

Designing new agents to fight inflammation using CO-Releasing Molecules (CORMs), from a structural point of view.

PTDC/QEQ-MED/1902/2014  "Nanoagentes de monoxido de carbono COGSs para combater a Artrite Reumatoide" (on-going) - Principal Investigator

Crystal structure of CORM-3-protein adduct (Santos-Silva T, et al, J Am Chem Soc. 2011 Feb 9;133(5):1192-5. doi:10.1021/ja108820s.)

How are CORMs interacting with plasma proteins?

PTDC/QUI-BIQ/117799/2010“Protein interaction with CO Releasing Molecules (CORM)” (finished - PI).


Molybdenum enzymes

Characterization of Mo-containing enzymes for future applications in drug development, bioremediation and biocatalysis.

PTDC/BBB-BEP/1185/2014 "Aldehyde Oxidases in Drug Metabolism and Biocatalysis: Searching for the Substrate Specificity and Catalytic Mechanism " (on-going, Team member).

PTDC/BBB-EBB/2723/2014 "Reduction of CO2 for sustainable biofuel production" (on-going, Team member).

PTDC/BIA-PRO/118377/2010 “Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation”(finished - PI).

Crystal structure of human aldehyde oxidase (Coelho C et al, Nat Chem Biol. 2015 Oct;11(10):779-83. doi: 10.1038/nchembio)