Research Assistant Professor in the Macromolecular Crystallography Research Lab at UCIBIO-FCT-NOVA, since November 2003

As Research Assistant Professor in the Macromolecular Crystallography Research Lab at Universidade NOVA de Lisboa, since November 2003, my main research interest has been the functional and structural characterization of different proteins, using the powerful information provided by X-ray Crystallography. The atomic level information obtained allows drawing conclusions related to macromolecular interactions, either protein-protein or protein-ligand.

Main research topics:

1) The functional and structural characterization of a megaDalton complex, the Cellulosome, present in some anaerobic bacteria and fungi. Read more

Related financed projects

  • as PI: PTDC/QUI-BIQ/100359/2008, PTDC/QUI/68286/2006 and PTDC/BBB-BEP/0869/2014
  • as member of research team: PTDC/BIA-MIC/5947/2014, EXPL/BBB-BEP/0506/2012, PTDC/QUI-QUI/112537/2009, PTDC/BIA-PRO/103980/2008 and POCI/PPCDT/BIA-PRO/59118/2004

(Thanks for the picture, Benedita!)

2) Structural characterization of proteins from different biological systems.

member of research team of projects: 

  • - PTDC/DTP-FTO/1981/2014 "ACTONP53: Targeting p53 family proteins: on the route to new anticancer agents", 
  • - "DeCellMab: Trifunctional antibodies and dendritic cell-based technologies: a combined approach to cancer immunotherapy" (Bluepharma/UCoimbra Award 2013), and 
  • - “Antibody Engineering for the Treatment of Breast Cancer” (Santander-Totta/NOVA Award 2012) 

3) Study of protein crystal growth and phasing using nanoparticles and/or ionic liquid compounds.

member of research team of project PTDC/BBB-BEP/3058/2012 “Novel approaches for protein crystallization using ionic liquid-based systems"

Lysozyme crystal grown from a neat ionic liquid (IL) solution with the IL cation and anion incorporated in the structure.

Peer-reviewing in:

  • Chemical Physics Letters
  • JBIC
  • Crystal Growth & Design
  • Journal of Applied Crystallography
  • Acta Crystallographica F ( Structural Biology and Crystallization Communications Online)

Online professional profiles