@article {4550,
	title = {Synthesis of MoS4 (2-)-M (M=Cu and Cd) Clusters: Potential NMR Spectroscopic Structural Probes for the Orange Protein},
	journal = {European Journal of Inorganic Chemistry},
	number = {26},
	year = {2012},
	note = {<p>Times Cited: 0 Maiti, Biplab K. Aviles, Teresa Matzapetakis, Manolis Moura, Isabel Pauleta, Sofia R. Moura, Jose J. G.</p>
},
	month = {Sep},
	pages = {4159-4166},
	abstract = {<p>Two synthetic strategies of tetrathiomolybdate-metal clusters with the potential to be used as NMR structural probes for the location of the metal cofactor in the orange protein (ORP) are described. The first strategy is based on the substitution reaction in which small organic ligands bind directly to the metal centre in a molybdenumcopper hetero-dinuclear cluster. Interaction between [PPh4]2[MoS4CuCl] and either aliphatic [beta-mercaptoethanol (b-me)] or aromatic [o-aminobenzenethiol (abt)] thiols in the presence of a strong base resulted in the formation of [Ph4P]2[S2MoS2Cu(b-me)] (1a) and [Et4N]2[S2MoS2Cu(abt)]center dot H2O center dot 0.25DMF (1b), which can be used to obtain intermolecular NOEs. The compound 1a readily hydrolyzed to [Ph4P]2[OSMoS2Cu(b-me)] (1ahydro) in contact with a protic solvent. The second strategy consisted of the incorporation of cadmium into tetrathiomolybdate ([MoS4]2), which gives rise to the trinuclear cluster compound [PPh4]2[(MoS4)2Cd] (2). All clusters were characterized spectroscopically and their structure determined by X-ray diffraction. The NMR spectroscopic data are consistent with the formation of a complex with a 1:1 ratio of {MoS4Cu} and thiol. The 113Cd NMR chemical shift of compound 2 is consistent with the cadmium having a tetrahedral geometry and coordinated by four sulfur ligands. The tetraphenylphosphonium cation in compound 1a was replaced by a tetramethylammonium countercation originating in the water-soluble compound [Me4N-1a]. Solubility in aqueous buffers is a requirement for incorporating this cluster into apo-ORP. These compounds will be used to identify the exact location of the ORP heterometallic cluster using NMR methodologies.</p>
},
	isbn = {1434-1948},
	url = {<Go to ISI>://WOS:000308401600007},
	author = {Maiti, B. K. and Aviles, T. and Matzapetakis, M. and Moura, I and Pauleta, S. R. and Moura, JJG}
}
