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Campanero-Rhodes, María Asunción, Angelina Sa Palma, Margarita Menéndez, and Dolores Solís. "{Microarray Strategies for Exploring Bacterial Surface Glycans and Their Interactions With Glycan-Binding Proteins.}." Frontiers in microbiology. 10 (2019): 2909. Abstract

Bacterial surfaces are decorated with distinct carbohydrate structures that may substantially differ among species and strains. These structures can be recognized by a variety of glycan-binding proteins, playing an important role in the bacteria cross-talk with the host and invading bacteriophages, and also in the formation of bacterial microcolonies and biofilms. In recent years, different microarray approaches for exploring bacterial surface glycans and their recognition by proteins have been developed. A main advantage of the microarray format is the inherent miniaturization of the method, which allows sensitive and high-throughput analyses with very small amounts of sample. Antibody and lectin microarrays have been used for examining bacterial glycosignatures, enabling bacteria identification and differentiation among strains. In addition, microarrays incorporating bacterial carbohydrate structures have served to evaluate their recognition by diverse host/phage/bacterial glycan-binding proteins, such as lectins, effectors of the immune system, or bacterial and phagic cell wall lysins, and to identify antigenic determinants for vaccine development. The list of samples printed in the arrays includes polysaccharides, lipopoly/lipooligosaccharides, (lipo)teichoic acids, and peptidoglycans, as well as sequence-defined oligosaccharide fragments. Moreover, microarrays of cell wall fragments and entire bacterial cells have been developed, which also allow to study bacterial glycosylation patterns. In this review, examples of the different microarray platforms and applications are presented with a view to give the current state-of-the-art and future prospects in this field.

Capodicasa, Cristina, Paola Chiani, Carla Bromuro, Flavia De Bernardis, Marcello Catellani, Angelina S. Palma, Yan Liu, Ten Feizi, Antonio Cassone, Eugenio Benvenuto, and Antonella Torosantucci. "Plant production of anti-beta-glucan antibodies for immunotherapy of fungal infections in humans." Plant Biotechnology Journal. 9 (2011): 776-787. Abstract
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Childs, Robert A., Angelina S. Palma, Steve Wharton, Tatyana Matrosovich, Yan Liu, Wengang Chai, Maria A. Campanero-Rhodes, Yibing Zhang, Markus Eickmann, Makoto Kiso, Alan Hay, Mikhail Matrosovich, and Ten Feizi. "Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray." Nature Biotechnology. 27 (2009): 797-799. Abstract
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Crusat, Martin, Junfeng Liu, Angelina S. Palma, Robert A. Childs, Yan Liu, Stephen A. Wharton, Yi Pu Lin, Peter J. Coombs, Stephen R. Martin, Mikhail Matrosovich, Zi Chen, David J. Stevens, Vo Minh Hien, Tran Tan Thanh, Le Nguyen Truc Nhu, Lam Anh Nguyet, Do Quang Ha, Rogier H. van Doorn, Tran Tinh Hien, Harald S. Conradt, Makoto Kiso, Steve J. Gamblin, Wengang Chai, John J. Skehel, Alan J. Hay, Jeremy Farrar, Menno D. de Jong, and Ten Feizi. "Changes in the hemagglutinin of H5N1 viruses during human infection - Influence on receptor binding." Virology. 447 (2013): 326-337. Abstract
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Dunlop, Cameron D., Camille Bonomelli, Fatma Mansab, Snezana Vasiljevic, Katie J. Doores, Mark R. Wormald, Angelina S. Palma, Ten Feizi, David J. Harvey, Raymond A. Dwek, Max Crispin, and Christopher N. Scanlan. "Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans." Glycobiology. 20 (2010): 812-823. Abstract
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Feizi, Ten, Yan Liu, and Angelina S. Palma. "Bacterial, Fungal, and Algal Lectins: Combatants in Tug of War against HIV." Structure. 19 (2011): 1035-1037. Abstract
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Friedrich, Nikolas, Joana M. Santos, Yan Liu, Angelina S. Palma, Ester Leon, Savvas Saouros, Makoto Kiso, Michael J. Blackman, Stephen Matthews, Ten Feizi, and Dominique Soldati-Favre. "Members of a Novel Protein Family Containing Microneme Adhesive Repeat Domains Act as Sialic Acid-binding Lectins during Host Cell Invasion by Apicomplexan Parasites." Journal of Biological Chemistry. 285 (2010): 2064-2076. Abstract
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Gao, Chao, Yan Liu, Hongtao Zhang, Yibing Zhang, Michiko N. Fukuda, Angelina S. Palma, Radoslaw P. Kozak, Robert A. Childs, Motohiro Nonaka, Zhen Li, Don L. Siegel, Peter Hanfland, Donna M. Peehl, Wengang Chai, Mark I. Greene, and Ten Feizi. "Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array." Journal of Biological Chemistry. 289 (2014): 16462-16477. Abstract
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Gao, Tian, Jingyu Yan, Chang-Cheng Liu, Angelina S. Palma, Zhimou Guo, Min Xiao, Xi Chen, Xinmiao Liang, Wengang Chai, and Hongzhi Cao. "{Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope.}." Journal of the American Chemical Society. 141 (2019): 19351-19359. Abstract

The human natural killer-1 (HNK-1) epitope is a unique sulfated trisaccharide sequence presented on O- and N-glycans of various glycoproteins and on glycolipids. It is overexpressed in the nervous system and plays crucial roles in nerve regeneration, synaptic plasticity, and neuronal diseases. However, the investigation of functional roles of HNK-1 in a more complex glycan context at the molecular level remains a big challenge due to lack of access to related structurally well-defined complex glycans. Herein, we describe a highly efficient chemoenzymatic approach for the first collective synthesis of HNK-1-bearing O-mannose glycans with different branching patterns, and for their nonsulfated counterparts. The successful strategy relies on both chemical glycosylation of a trisaccharide lactone donor for the introduction of sulfated HNK-1 branch and substrate promiscuities of bacterial glycosyltransferases that can tolerate sulfated substrates for enzymatic diversification. Glycan microarray analysis with the resulting complex synthetic glycans demonstrated their recognition by two HNK-1-specific antibodies including anti-HNK-1/N-CAM (CD57) and Cat-315, which provided further evidence for the recognition epitopes of these antibodies and the essential roles of the sulfate group for HNK-1 glycan-antibody recognition.

Gomes, Catarina, Angelina S. Palma, Rui Almeida, Manuela Regalla, Leo F. McCluskey, John Q. Trojanowski, and Julia Costa. "Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis." Biotechnology Letters. 30 (2008): 603-610. Abstract
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Graham, Lisa M., Vandana Gupta, Georgia Schafer, Delyth M. Reid, Matti Kimberg, Kevin M. Dennehy, William G. Hornsell, Reto Guler, Maria A. Campanero-Rhodes, Angelina S. Palma, Ten Feizi, Stella K. Kim, Peter Sobieszczuk, Janet A. Willment, and Gordon D. Brown. "The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase." Journal of Biological Chemistry. 287 (2012): 25964-25974. Abstract
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Lai, Livia, Janene Bumstead, Yan Liu, James Garnett, Maria A. Campanero-Rhodes, Damer P. Blake, Angelina S. Palma, Wengang Chai, David J. P. Ferguson, Peter Simpson, Ten Feizi, Fiona M. Tomley, and Stephen Matthews. "The Role of Sialyl Glycan Recognition in Host Tissue Tropism of the Avian Parasite Eimeria tenella." Plos Pathogens. 7 (2011). Abstract
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Li, Z., C. Gao, Y. Zhang, A. S. Palma, and et al. "O-Glycome Beam Search Arrays for Carbohydrate Ligand Discovery." Mol Cell Proteomics. 17.1 (2018): 121-133.
Liu, Yan, Angelina S. Palma, Wengang Chai, Claudia Muhle-Goll, Yukishige Ito, and Ten Feizi. "The Latest on Malectin - A Lectin of the Endoplasmic Reticulum." Glycobiology. 19 (2009): 1301-1302. Abstract
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Liu, Yan, Robert A. Childs, Tatyana Matrosovich, Stephen Wharton, Angelina S. Palma, Wengang Chai, Rodney Daniels, Victoria Gregory, Jennifer Uhlendorff, Makoto Kiso, Hans-Dieter Klenk, Alan Hay, Ten Feizi, and Mikhail Matrosovich. "Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus." Journal of Virology. 84 (2010): 12069-12074. Abstract
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Liu, Yan, Angelina S. Palma, and Ten Feizi. "Carbohydrate microarrays: key developments in glycobiology." Biological Chemistry. 390 (2009): 647-656. Abstract
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Liu, Y., A. S. Palma, T. Feizi, and W. Chai. "Insights Into Glucan Polysaccharide Recognition Using Glucooligosaccharide Microarrays With Oxime-Linked Neoglycolipid Probes." Methods Enzymol.. 598 (2018): 139-167.
Liu, Yan, Robert A. Childs, Angelina S. Palma, Maria A. Campanero-Rhodes, Mark S. Stoll, Wengang Chai, and Ten Feizi. "Neoglycolipid-based oligosaccharide microarray system: preparation of NGLs and their noncovalent immobilization on nitrocellulose-coated glass slides for microarray analyses." Methods in molecular biology (Clifton, N.J.). 808 (2012): 117-36. Abstract
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Loureiro, LR, DP Sousa, D. Ferreira, W. Chai, L. Lima, C. Pereira, CB Lopes, VG Correia, LM Silva, C. Li, LL Santos, JA Ferreira, A. Barbas, A. S. Palma, C. Novo, and PA Videira. "Novel Monoclonal Antibody L2A5 Specifically Targeting sialyl-Tn and Short Glycans Terminated by alpha-2-6 Sialic Acids." Sci Rep.. 8.1 (2018): 12196.
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Mollegaard, Karen Mai, Karen Duus, Sofie Dietz Traeholt, Morten Thaysen-Andersen, Yan Liu, Angelina S. Palma, Ten Feizi, Paul R. Hansen, Peter Hojrup, and Gunnar Houen. "The interactions of calreticulin with immunoglobulin G and immunoglobulin Y." Biochimica Et Biophysica Acta-Proteins and Proteomics. 1814 (2011): 889-899. Abstract
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Murugesan, Gavuthami, Viviana G. Correia, Angelina S. Palma, Wengang Chai, Chunxia Li, Ten Feizi, Eva Martin, Brigitte Laux, Alexandra Franz, Klaus Fuchs, Bernd Weigle, and Paul R. Crocker. "Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression." Glycobiology (2020). Abstract

Siglec-15 is a conserved sialic acid-binding Ig-like lectin expressed on osteoclast progenitors that plays an important role in osteoclast development and function. It is also expressed by tumor-associated macrophages and by some tumors, where it is thought to contribute to the immunosuppressive microenvironment. It was shown previously that engagement of macrophage-expressed Siglec-15 with tumor cells expressing its ligand, sialyl Tn (sTn), triggered production of TGF-$\beta$. In the present study, we have further investigated the interaction between Siglec-15 and sTn on tumor cells and its functional consequences. Based on binding assays with lung and breast cancer cell lines and glycan-modified cells, we failed to see evidence for recognition of sTn by Siglec-15. However, using a microarray of diverse, structurally-defined glycans, we show that Siglec-15 binds with higher avidity to sialylated glycans other than sTn or related antigen sequences. In addition, we were unable to demonstrate enhanced TGF-$\beta$ secretion following co-culture of Siglec-15-expressing monocytic cells lines with tumor cells expressing sTn, or following Siglec-15 cross-linking with monoclonal antibodies. However, we did observe activation of the SYK/MAPK signaling pathway following antibody cross-linking of Siglec-15 that may modulate the functional activity of macrophages.

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Neu, Ursula, Zaigham Mahmood Khan, Benjamin Schuch, Angelina S. Palma, Yan Liu, Michael Pawlita, Ten Feizi, and Thilo Stehle. "Structures of B-Lymphotropic Polyomavirus VP1 in Complex with Oligosaccharide Ligands." PLoS pathogens. 9 (2013): e1003714. Abstract
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Neu, Ursula, Melissa S. Maginnis, Angelina S. Palma, Luisa J. Stroeh, Christian D. S. Nelson, Ten Feizi, Walter J. Atwood, and Thilo Stehle. "Structure-Function Analysis of the Human JC Polyomavirus Establishes the LSTc Pentasaccharide as a Functional Receptor Motif." Cell Host & Microbe. 8 (2010): 309-319. Abstract
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Neu, Ursula, Stacy-Ann A. Allen, Barbel S. Blaum, Yan Liu, Martin Frank, Angelina S. Palma, Luisa J. Stroh, Ten Feizi, Thomas Peters, Walter J. Atwood, and Thilo Stehle. "A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus." PLoS pathogens. 9 (2013): e1003688. Abstract
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