Publications

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Palma, Angelina S., Ten Feizi, Robert A. Childs, Wengang Chai, and Yan Liu. "The neoglycolipid (NGL)-based oligosaccharide microarray system poised to decipher the meta-glycome." Current Opinion in Chemical Biology. 18 (2014): 87-94. Abstract
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Palma, A., M. De Carvalho, N. Barata, T. Evangelista, P. Chicau, M. REGALLA, and J. Costa. "Biochemical characterization of plasma in amyotrophic lateral sclerosis: Amino acid and protein composition." Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 6 (2005): 104-110. Abstract
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Palma, Angelina S., Yan Liu, Yibing Zhang, Hongtao Zhang, Ana S. Luis, Ana Luisa Carvalho, Harry J. Gilbert, Alisdair Boraston, Carlos M. G. A. Fontes, Wengang Chai, and Ten Feizi. "Designer-oligosaccharide microarrays to decipher ligands in mammalian and prokaryotic glucan-recognition systems." Glycobiology. 22 (2012): 1612-1613. Abstract
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Palma, A. S., VA Morais, AV Coelho, and J. Costa. "Effect of the manganese ion on human alpha 3/4 fucosyltransferase III activity." Biometals. 17 (2004): 35-43. Abstract
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Palma, Angelina S., Yan Liu, Maria A. Campanero-Rhodes, Robert A. Childs, Mark S. Stoll, Thomas Schallus, Claudia Muhle-Goll, Mukram Mackeen, Wengang Chai, and Ten Feizi. "Malectin-a Novel Lectin of the Endoplasmic Reticulum and a Candidate New Player in the Early Steps Of Protein N-Glycosylation." Glycobiology. 18 (2008): 948-949. Abstract
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Palma, Angelina S., Yibing Zhang, Robert A. Childs, Maria A. Campanero-Rhodes, Yan Liu, Ten Feizi, and Wengang Chai. "Neoglycolipid-based "designer" oligosaccharide microarrays to define beta-glucan ligands for Dectin-1." Methods in molecular biology (Clifton, N.J.). 808 (2012): 337-59. Abstract
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Palma, Angelina S., Benedita Pinheiro, Yan Liu, Yoichi Takeda, Wengang Chai, Yukishige Ito, Maria Joao Romao, Ana Luisa Carvalho, and Ten Feizi. "The Structural Basis of the Recognition of Di-glucosylated N-glycans by the ER Lectin Malectin." Glycobiology. 23 (2013): 1368-1369. Abstract
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Palma, A. S., C. Vila-Verde, AS Pires, PS Fevereiro, and J. Costa. "A novel plant alpha 4-fucosyltransferase (Vaccinium myrtillus L.) synthesises the Lewis(a) adhesion determinant." Febs Letters. 499 (2001): 235-238. Abstract
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Palma, Angelina S., Yan Liu, Robert A. Childs, Colin Herbert, Denong Wang, Wengang Chai, and Ten Feizi. "The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins." Biochemical and Biophysical Research Communications. 408 (2011): 548-552. Abstract
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Palma, Angelina S., Mamede De Carvalho, Nicolas Grammel, Susana Pinto, Nuno Barata, Harald S. Conradt, and Julia Costa. "Proteomic analysis of plasma from Portuguese patients with familial amyotrophic lateral sclerosis." Amyotrophic Lateral Sclerosis. 9 (2008): 339-349. Abstract
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Palma, A. S., T. Feizi, YB Zhang, MS Stoll, AM Lawson, E. Diaz-Rodriguez, MA Campanero-Rhodes, J. Costa, S. Gordon, GD Brown, and WG Chai. "Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides." Journal of Biological Chemistry. 281 (2006): 5771-5779. Abstract
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Palma, Angelina S., Yan Liu, Claudia Muhle-Goll, Terry D. Butters, Yibing Zhang, Robert Childs, Wengang Chai, Ten Feizi, and M. Fukuda. "MULTIFACETED APPROACHES INCLUDING NEOGLYCOLIPID OLIGOSACCHARIDE MICROARRAYS TO LIGAND DISCOVERY FOR MALECTIN." Methods in Enzymology, Vol 478: Glycomics. 478 (2010): 265-286. Abstract
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Palma, Angelina S., Yan Liu, Hongtao Zhang, Yibing Zhang, Barry V. McCleary, Guangli Yu, Qilin Huang, Leticia S. Guidolin, Andres E. Ciocchini, Antonella Torosantucci, Denong Wang, Ana Luisa Carvalho, Carlos M. G. A. Fontes, Barbara Mulloy, Robert A. Childs, Ten Feizi, and Wengang Chai. "Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry." Molecular & Cellular Proteomics. 14 (2015): 974-988. Abstract
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Pandeirada, Carolina O., Élia Maricato, Sónia S. Ferreira, Viviana G. Correia, Benedita A. Pinheiro, Dmitry V. Evtuguin, Angelina S. Palma, Alexandra Correia, Manuel Vilanova, Manuel A. Coimbra, and Cláudia Nunes. "{Structural analysis and potential immunostimulatory activity of Nannochloropsis oculata polysaccharides.}." Carbohydrate polymers. 222 (2019): 114962. Abstract

The relevance of microalgae biotechnology for producing high-value compounds with biomedical application, such as polysaccharides, has been increasing. Despite this, the knowledge about the composition and structure of microalgae polysaccharides is still scarce. In this work, water-soluble polysaccharides from Nannochloropsis oculata were extracted, fractionated, structurally analysed, and subsequently tested in terms of immunostimulatory activity. A combination of sugar and methylation analysis with interaction data of carbohydrate-binding proteins using carbohydrate microarrays disclosed the complex structural features of the different polysaccharides. These analyses showed that the water-soluble polysaccharides fractions from N. oculata were rich in ($\beta$1→3, $\beta$1→4)-glucans, ($\alpha$1→3)-, ($\alpha$1→4)-mannans, and anionic sulphated heterorhamnans. The immunostimulatory assay highlighted that these fractions could also stimulate murine B-lymphocytes. Thus, the N. oculata water-soluble polysaccharides show potential to be further explored for immune-mediated biomedical applications.