<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Guimarães, Diana</style></author><author><style face="normal" font="default" size="100%">Carvalho, Maria Luisa</style></author><author><style face="normal" font="default" size="100%">Geraldes, Vera</style></author><author><style face="normal" font="default" size="100%">Rocha, Isabel</style></author><author><style face="normal" font="default" size="100%">Alves, Luís Cerqueira</style></author><author><style face="normal" font="default" size="100%">Santos, Jose Paulo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lead in liver and kidney of exposed rats: Aging accumulation study.</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Trace Elements in Medicine and Biology</style></secondary-title><short-title><style face="normal" font="default" size="100%">JPS_Articles Rats_Hair_JTEMB_2015 Q2, 2.491</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0946672X12000090</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">26</style></volume><pages><style face="normal" font="default" size="100%">285</style></pages><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The concentration of lead in liver and kidneys of Wistar rats, fed with lead since fetal period in relation to their age and to a control group, was determined. A group of rats was exposed to lead acetate (n=30) in drinking water and the other group was exposed to normal water (n=20). Samples were collected from rats aging between 1 and 11 months and were analyzed by Energy Dispersive X-ray Fluorescence (EDXRF) without any chemical preparation. The EDXRF results were assessed by the PIXE (Proton Induced X-ray Emission) technique. The formaldehyde used to preserve the samples was also analyzed by ETAAS (Electro-Thermal Atomic Absorption Spectrometry) in order to verify if there was any loss of lead from the samples to the formaldehyde. We found that the loss was not significant (&amp;lt;2%). Concerning the mean values of the lead concentration measured in the contaminated soft tissues, in liver they range from 6 to 22μgg(-1), and in kidneys from 44 to 79μgg(-1). The control rats show, in general, values below the EDXRF detection limit (2μgg(-1)). The ratio kidney/liver ranges from 2 to 10 and is strongly positively correlated with the age of the animals. A Spearman correlation matrix to investigate the correlation between elemental concentrations and the dependence of these concentrations with age showed that there is a strong positive correlation with age for lead in the liver but not in the kidney. The correlation matrix showed also that the concentration of lead in these two soft tissues is not correlated. The lead accumulation in liver is made by different plateaus that strongly decrease with age. It was verified the existence of two levels of accumulation in kidney, not very highlighted, which might be indicative of a maximum accumulation level for lead in kidney.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">22683051</style></accession-num><notes><style face="normal" font="default" size="100%">n/a</style></notes><custom3><style face="normal" font="default" size="100%">papers3://publication/uuid/99CCA166-1938-4858-8C04-C12C1F0701D9</style></custom3><auth-address><style face="normal" font="default" size="100%">Centro de Física Atómica, CFA, Departamento de Física, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa, 2829-516 Monte da Caparica, Portugal. Electronic address: dianafcg@gmail.com.</style></auth-address><label><style face="normal" font="default" size="100%">r04275</style></label></record></records></xml>