@article {Aroso2015a,
	title = {{Design of controlled release systems for THEDES - Therapeutic deep eutectic solvents, using supercritical fluid technology}},
	journal = {International Journal of Pharmaceutics},
	volume = {492},
	number = {1-2},
	year = {2015},
	note = {n/a},
	abstract = {<p>{\textcopyright} 2015 Elsevier B.V. Abstract Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch:poly-{\"I}$μ$-caprolactone polymeric blend (SPCL 30:70) with the menthol:ibuprofen THEDES in different ratios (10 and 20 wt{\%}), after supercritical fluid sintering at 20 MPa and 50 {\textdegree}C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and micro-computed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds.</p>
},
	keywords = {Biodegradable polymers, Drug delivery systems, Ibuprofen, supercritical carbon dioxide, Therapeutic deep eutectic solvents},
	issn = {18733476},
	doi = {10.1016/j.ijpharm.2015.06.038},
	author = {Aroso, I.M. and Craveiro, R. and Rocha, {\^A}. and M. Dion{\'\i}sio and S. Barreiros and Reis, R.L. and Paiva, A. and Duarte, A.R.C.}
}
