<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paula S. Branco</style></author><author><style face="normal" font="default" size="100%">Peixoto, Daniela</style></author><author><style face="normal" font="default" size="100%">Figueiredo, Margarida</style></author><author><style face="normal" font="default" size="100%">Malta, Gabriela</style></author><author><style face="normal" font="default" size="100%">Roma-Rodrigues, Catarina</style></author><author><style face="normal" font="default" size="100%">Batista, Pedro Viana</style></author><author><style face="normal" font="default" size="100%">Fernandes, Alexandra R.</style></author><author><style face="normal" font="default" size="100%">Barroso, Sónia</style></author><author><style face="normal" font="default" size="100%">Carvalho, Ana Luisa</style></author><author><style face="normal" font="default" size="100%">Afonso, Carlos A. M.</style></author><author><style face="normal" font="default" size="100%">Ferreira, Luísa Maria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis, cytotoxicity evaluation in human cell lines and in vitro DNA interaction of a hetero arylidene-9(10H)-anthrone</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Organic Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">anthracenecarboxaldehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">arylidene anthrone</style></keyword><keyword><style  face="normal" font="default" size="100%">Decarbonylation</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA intercalation</style></keyword><keyword><style  face="normal" font="default" size="100%">Imidazolium salt</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1002/ejoc.201701500</style></url></web-urls></urls><pages><style face="normal" font="default" size="100%">n/a–n/a</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A new and never yet reported hetero arylidene-9(10H)-anthrone structure (4) was unexpectedly isolated on reaction of 1,2-dimethyl-3-ethylimidazolium iodide (2) and 9-anthracenecarboxaldehyde (3) under basic conditions. Its structure was unequivocally attributed by X-ray crystallography. No cytotoxicity in human healthy fibroblasts and in two different cancer cell lines was observed indicating its applicability in biological systems. Compound 4 interacts with CT-DNA by intercalation between the adjacent base pairs of DNA with a high binding affinity (Kb = 2.0(± 0.20) x 105 M-1) which is 10x higher than that described for doxorubicin (Kb = 3.2 (±0.23) × 104 M-1). Furthermore, compound 4 quenches the fluorescence emission of GelRed-CT-DNA system with a quenching constant (KSV) of 3.3(±0.3) x 103 M-1 calculated by the Stern-Volmer equation.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">&lt;p&gt;n/a&lt;/p&gt;
</style></notes></record></records></xml>