Organic Synthesis and Chemical Biology


Maria Manuel M. S. Barata Marques joined the group of Prof Johann Mulzer (2001-2003) and on  May 2003 joined REQUIMTE. Since then our main research activities have been focused on:

  • Synthesis of glycopeptides involved in cellualr recognition processes
  • Synthesis of heterocyclic and biologically active compounds, in particular indole and benzimidazole based compounds (with anti-inflammatory properties)
  • Rational drug design - small molecules approach
  • Development of novel methodologies in organic synthesis

Ongoing Research Projects

Our research is focused on the development of novel synthetic strategies towards bioactive compounds. Two main research topics are currently being developed:

1) synthesis of complex glycoconjugates involved in cellular recognition processes. The ultimate goal is the synthesis of glycoconjugates and the study of their interaction with crucial proteins involved in important cellular pathways;

2) a rational drug design approach towards novel anti-inflammatory drugs – a small molecule (heterocyclic structures) approach.