Publications

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Journal Article
Liu, Yan, Robert A. Childs, Tatyana Matrosovich, Stephen Wharton, Angelina S. Palma, Wengang Chai, Rodney Daniels, Victoria Gregory, Jennifer Uhlendorff, Makoto Kiso, Hans-Dieter Klenk, Alan Hay, Ten Feizi, and Mikhail Matrosovich. "Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus." Journal of Virology. 84 (2010): 12069-12074. Abstract
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Feizi, Ten, Yan Liu, and Angelina S. Palma. "Bacterial, Fungal, and Algal Lectins: Combatants in Tug of War against HIV." Structure. 19 (2011): 1035-1037. Abstract
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Palma, A., M. De Carvalho, N. Barata, T. Evangelista, P. Chicau, M. REGALLA, and J. Costa. "Biochemical characterization of plasma in amyotrophic lateral sclerosis: Amino acid and protein composition." Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 6 (2005): 104-110. Abstract
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Graham, Lisa M., Vandana Gupta, Georgia Schafer, Delyth M. Reid, Matti Kimberg, Kevin M. Dennehy, William G. Hornsell, Reto Guler, Maria A. Campanero-Rhodes, Angelina S. Palma, Ten Feizi, Stella K. Kim, Peter Sobieszczuk, Janet A. Willment, and Gordon D. Brown. "The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase." Journal of Biological Chemistry. 287 (2012): 25964-25974. Abstract
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Liu, Yan, Angelina S. Palma, and Ten Feizi. "Carbohydrate microarrays: key developments in glycobiology." Biological Chemistry. 390 (2009): 647-656. Abstract
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Gao, Chao, Yan Liu, Hongtao Zhang, Yibing Zhang, Michiko N. Fukuda, Angelina S. Palma, Radoslaw P. Kozak, Robert A. Childs, Motohiro Nonaka, Zhen Li, Don L. Siegel, Peter Hanfland, Donna M. Peehl, Wengang Chai, Mark I. Greene, and Ten Feizi. "Carbohydrate Sequence of the Prostate Cancer-associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array." Journal of Biological Chemistry. 289 (2014): 16462-16477. Abstract
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Crusat, Martin, Junfeng Liu, Angelina S. Palma, Robert A. Childs, Yan Liu, Stephen A. Wharton, Yi Pu Lin, Peter J. Coombs, Stephen R. Martin, Mikhail Matrosovich, Zi Chen, David J. Stevens, Vo Minh Hien, Tran Tan Thanh, Le Nguyen Truc Nhu, Lam Anh Nguyet, Do Quang Ha, Rogier H. van Doorn, Tran Tinh Hien, Harald S. Conradt, Makoto Kiso, Steve J. Gamblin, Wengang Chai, John J. Skehel, Alan J. Hay, Jeremy Farrar, Menno D. de Jong, and Ten Feizi. "Changes in the hemagglutinin of H5N1 viruses during human infection - Influence on receptor binding." Virology. 447 (2013): 326-337. Abstract
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Palma, Angelina S., Yan Liu, Yibing Zhang, Hongtao Zhang, Ana S. Luis, Ana Luisa Carvalho, Harry J. Gilbert, Alisdair Boraston, Carlos M. G. A. Fontes, Wengang Chai, and Ten Feizi. "Designer-oligosaccharide microarrays to decipher ligands in mammalian and prokaryotic glucan-recognition systems." Glycobiology. 22 (2012): 1612-1613. Abstract
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Palma, A. S., VA Morais, AV Coelho, and J. Costa. "Effect of the manganese ion on human alpha 3/4 fucosyltransferase III activity." Biometals. 17 (2004): 35-43. Abstract
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Gomes, Catarina, Angelina S. Palma, Rui Almeida, Manuela Regalla, Leo F. McCluskey, John Q. Trojanowski, and Julia Costa. "Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis." Biotechnology Letters. 30 (2008): 603-610. Abstract
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Zhang, H., A. S. Palma, Y. Zhang, R. A. Childs, Y. Liu, D. A. Mitchell, L. S. Guidolin, W. Weigel, B. Mulloy, A. E. Ciocchini, T. Feizi, and W. Chai. "Generation and characterization of β1,2-gluco-oligosaccharide probes from Brucella abortus cyclic β-glucan and their recognition by C-type lectins of the immune system." Glycobiology (2016). AbstractWebsite
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Palma, Angelina S., Yan Liu, Robert A. Childs, Colin Herbert, Denong Wang, Wengang Chai, and Ten Feizi. "The human epithelial carcinoma antigen recognized by monoclonal antibody AE3 is expressed on a sulfoglycolipid in addition to neoplastic mucins." Biochemical and Biophysical Research Communications. 408 (2011): 548-552. Abstract
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Silva, Lisete, Robert A. Childs, Angelina S. Palma, Wengang Chai, Ten Feizi, and Yan Liu. "Influence of carrier lipid composition on glycan recognition in NGL-based microarrays." Glycobiology. 25 (2015): 1260. Abstract
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Liu, Y., A. S. Palma, T. Feizi, and W. Chai. "Insights Into Glucan Polysaccharide Recognition Using Glucooligosaccharide Microarrays With Oxime-Linked Neoglycolipid Probes." Methods Enzymol.. 598 (2018): 139-167.
Mollegaard, Karen Mai, Karen Duus, Sofie Dietz Traeholt, Morten Thaysen-Andersen, Yan Liu, Angelina S. Palma, Ten Feizi, Paul R. Hansen, Peter Hojrup, and Gunnar Houen. "The interactions of calreticulin with immunoglobulin G and immunoglobulin Y." Biochimica Et Biophysica Acta-Proteins and Proteomics. 1814 (2011): 889-899. Abstract
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Liu, Yan, Angelina S. Palma, Wengang Chai, Claudia Muhle-Goll, Yukishige Ito, and Ten Feizi. "The Latest on Malectin - A Lectin of the Endoplasmic Reticulum." Glycobiology. 19 (2009): 1301-1302. Abstract
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Palma, A. S., T. Feizi, YB Zhang, MS Stoll, AM Lawson, E. Diaz-Rodriguez, MA Campanero-Rhodes, J. Costa, S. Gordon, GD Brown, and WG Chai. "Ligands for the beta-glucan receptor, Dectin-1, assigned using "designer" microarrays of oligosaccharide probes (neoglycolipids) generated from glucan polysaccharides." Journal of Biological Chemistry. 281 (2006): 5771-5779. Abstract
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Sousa, VL, MT Costa, A. S. Palma, F. Enguita, and J. Costa. "Localization, purification and specificity of the full-length membrane-bound form of human recombinant alpha 1,3/4-fucosyltransferase from BHK-21B cells." Biochemical Journal. 357 (2001): 803-810. Abstract
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Palma, Angelina S., Yan Liu, Maria A. Campanero-Rhodes, Robert A. Childs, Mark S. Stoll, Thomas Schallus, Claudia Muhle-Goll, Mukram Mackeen, Wengang Chai, and Ten Feizi. "Malectin-a Novel Lectin of the Endoplasmic Reticulum and a Candidate New Player in the Early Steps Of Protein N-Glycosylation." Glycobiology. 18 (2008): 948-949. Abstract
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Schallus, Thomas, Christine Jaeckh, Krisztina Feher, Angelina S. Palma, Yan Liu, Jeremy C. Simpson, Mukram Mackeen, Gunter Stier, Toby J. Gibson, Ten Feizi, Tomas Pieler, and Claudia Muhle-Goll. "Malectin: A novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation." Molecular Biology of the Cell. 19 (2008): 3404-3414. Abstract
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Friedrich, Nikolas, Joana M. Santos, Yan Liu, Angelina S. Palma, Ester Leon, Savvas Saouros, Makoto Kiso, Michael J. Blackman, Stephen Matthews, Ten Feizi, and Dominique Soldati-Favre. "Members of a Novel Protein Family Containing Microneme Adhesive Repeat Domains Act as Sialic Acid-binding Lectins during Host Cell Invasion by Apicomplexan Parasites." Journal of Biological Chemistry. 285 (2010): 2064-2076. Abstract
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Ribeiro, Diana O., Aldino Viegas, Virgínia M. R. Pires, João Medeiros-Silva, Pedro Bule, Wengang Chai, Filipa Marcelo, Carlos M. G. A. Fontes, Eurico J. Cabrita, Angelina S. Palma, and Ana Luísa Carvalho. "Molecular basis for the preferential recognition of beta 1,3-1,4-glucans by the family 11 carbohydrate-binding module from Clostridium thermocellum." The FEBS journal. 287 (2020): 2723-2743. Abstract

Understanding the specific molecular interactions between proteins and $\beta$1,3-1,4-mixed-linked d-glucans is fundamental to harvest the full biological and biotechnological potential of these carbohydrates and of proteins that specifically recognize them. The family 11 carbohydrate-binding module from Clostridium thermocellum (CtCBM11) is known for its binding preference for $\beta$1,3-1,4-mixed-linked over $\beta$1,4-linked glucans. Despite the growing industrial interest of this protein for the biotransformation of lignocellulosic biomass, the molecular determinants of its ligand specificity are not well defined. In this report, a combined approach of methodologies was used to unravel, at a molecular level, the ligand recognition of CtCBM11. The analysis of the interaction by carbohydrate microarrays and NMR and the crystal structures of CtCBM11 bound to $\beta$1,3-1,4-linked glucose oligosaccharides showed that both the chain length and the position of the $\beta$1,3-linkage are important for recognition, and identified the tetrasaccharide Glc$\beta$1,4Glc$\beta$1,4Glc$\beta$1,3Glc sequence as a minimum epitope required for binding. The structural data, along with site-directed mutagenesis and ITC studies, demonstrated the specificity of CtCBM11 for the twisted conformation of $\beta$1,3-1,4-mixed-linked glucans. This is mediated by a conformation-selection mechanism of the ligand in the binding cleft through CH-$π$ stacking and a hydrogen bonding network, which is dependent not only on ligand chain length, but also on the presence of a $\beta$1,3-linkage at the reducing end and at specific positions along the $\beta$1,4-linked glucan chain. The understanding of the detailed mechanism by which CtCBM11 can distinguish between linear and mixed-linked $\beta$-glucans strengthens its exploitation for the design of new biomolecules with improved capabilities and applications in health and agriculture. DATABASE: Structural data are available in the Protein Data Bank under the accession codes 6R3M and 6R31.