GlycoLab - Functional Glycobiology

Group Leader

Angelina S. Palma

Research Assistant Professor

Office: 634; FCT Telephone: (+351) 212948300; Extension: 10940; Fax: (+351) 212948550; 

Email: angelina.palma [at] fct.unl.pt@ UCIBIO: http://www.requimte.pt/ucibio/people/angelinapalma

Associated Researchers 

 

Ana Luísa Carvalho


Research Assistant Professor

I am an integrated member of Research Unit UCIBIO, developing research work in the Macromolecular Crystallography Group. For many years, my main research interest has been the functional and structural characterization of a megaDalton complex, the Cellulosome, present in some anaerobic bacteria and fungi. Find more about my research, and the projects i coordinate, in my website: http://docentes.fct.unl.pt/almc/. In 2009, Angelina and I started a fruitful research collaboration that brings together the high throughput power of Glycan Microarrays and X-ray Crystallography. Presently, we share lab resources and the supervision of 2 PhD students, 2 MSc students and 1 Post-Doctoral Fellow.

Office: 634; FCT Telephone: (+351) 212948300; Extension: 10940; Fax: (+351) 21294855; 

Email: almc [at] fct.unl.pt; @ UCIBIO: http://www.requimte.pt/ucibio/people/ana-luisa-carvalho

Benedita Pinheiro

Post-Doctoral Fellow

I am a Post-Doctoral Fellow in the Macromolecular Crystallography Group in the Research Unit UCIBIO. I have obtained a PhD in Animal Science and Technology in 2010, in the Technical University of Lisbon (presently University of Lisbon), studying the assembly and function of the bacterial multi-enzymatic complex involved in plant cell all carbohydrate degradation, the cellulosome. I am particularly interested in the protein-protein cohesin-dockerin interaction and in the study of carbohydrate-interacting proteins such as lectins and carbohydrate binding modules (CBMs). Being a member of the GlycoLab from the beginning, I have been involved in its setup and in the broadening of its scope through the implementation of protein microarrays. I am currently contributing to the ongoing GlycoLab projects with my expertise in molecular biology, protein production and X-ray crystallography. One of our joint projects is on solving the first X-ray 3D structure of human malectin in complex with its endogenous glycan ligand, with insights into its recognition in the Endoplasmic Reticulum and malectin evolution and function in protein quality control in mammals. 

Office: 634; FCT Telephone: (+351) 212948300; Extension: 10940; Fax: (+351) 212948550; 

Email: b.pinheiro [at] fct.unl.pt@ UCIBIO: http://www.requimte.pt/ucibio/people/bpinheiro

Lisete Silva

Post-Doctoral Fellow (former PhD student)

I obtained my BSc and MSc degrees in Chemistry at the Faculty of Sciences, Porto University (Portugal). My PhD degree in Biochemistry, funded by the Portuguese Foundation for Science and Technology, was carried out at University of Aveiro (Portugal) under Supervision of Professor Manuel A. Coimbra with co-supervisors Dr. Angelina Palma (NOVA University of Lisbon, Portugal) and Dr. José A. Ferreira (Portuguese Institute of Oncology Porto). My PhD was focused on the structural analysis of lipopolysaccharides (LPSs) of Helicobacter pylori by GC-MS and ESI-MS/MSn and development of microarrays of the LPSs for interrogation of host recognition using glycan binding proteins or infected serum. During my PhD studies, I was introduced and trained in protein biology, glycobiology and glycan microarrays by Dr Angelina Palma. As my background was in Chemistry, this was a turning point in my research path, and since obtaining my PhD I started my postdoctoral studies in the Glycosciences Laboratory in March 2015 (https://www1.imperial.ac.uk/glycosciences/people/lisete_silva/). My research involves the investigation of different formulations of lipid-linked glycan probes in neoglycolipid (NGL)-based microarrays, and the binding signals they elicit in microarray analyses. I have been closely involved in the construction of a new version of a broad spectrum microarray of ~900 glycan probes for the Wellcome-Trust funded Carbohydrate Microarray Facility for applications in high throughput analyses of proteins from various sources of biological and medical impact. I am closely collaborating with Dr Angelina Palma in specific glycan microarray projects and glycan microarray construction.